An analytical device for detecting nasal drug delivery

Abstract

The invention discloses an analysis device for detecting nasal drug administration, which is characterized in that the analysis device includes an elbow (1) as a part of the nasal cavity, and the elbow (1) consists of a drug feeding tube as a nasal vestibule (2) and the receiving tube (3) as the middle meatus, the receiving device (4) as the maxillary sinus is arranged on the lumen of the receiving tube (3), and the receiving tube (3) on the front side of the receiving device (4) ) The pipe wall is provided with a crack (5) as a half-lunar hole and the receiving device (4) is provided with a top cover for sampling or cleaning. The analysis device of the present invention is used to simulate the structure of nasal cavity, maxillary sinus and ostium-nasal cavity complex, the analysis device is used for in vitro equivalence detection of nasal atomization inhalation, and can quantitatively detect the drug content in maxillary sinus after nasal atomization administration , Quantitative analysis of the drug content in the maxillary sinus after nasal atomization is used to evaluate the quality of drug nasal atomization preparations.

Description

technical field [0001] The invention relates to the technical field of drug analysis, in particular to a nasal drug detection device capable of simulating the nasal cavity, the maxillary sinus and the ostium-nasal complex and quantitatively analyzing the drug content in the maxillary sinus after nasal atomization. analysis device. Background technique [0002] Nasal sinuses include maxillary sinus, ethmoid sinus, frontal sinus, and sphenoid sinus. Among them, there is one left and right maxillary sinus, which is located between the floor of the orbit, the outer side of the nasal cavity and the upper part of the hard palate of the oral cavity. It opens in the middle meatus of the nasal cavity. Inflammation of one or more sinuses is called sinusitis, and maxillary sinusitis is a type of sinusitis. At present, there are two ways to treat sinusitis, one is surgical treatment; the other is drug treatment. During the treatment, the nasal atomization liquid can be introduced into ...

AI Technical Summary

Problems solved by technology

Most of the drug administration methods for treating sinusitis on the market cannot effectively enter the sinuses, and there is no effective in vitro detection and analysis device, and there is a lack of clear in vitro indicators for the quality control of the preparations

Most patients with sinusitis have maxillary sinusitis, because the maxillary sinus ostium is relatively small, especially in the case of sinusitis, the sinus ostium may be smaller, which makes treatment difficult. The in vivo analysis of the incoming drug content may easily lead to poor repeatability due to large individual differences. There is no corresponding analysis device for drug evaluation in vitro, and it is difficult to control the quality of pharmaceutical preparations

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