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Large length-diameter ratio plane metal microneedle array, preparation method and clamping and penetration auxiliary devices of large length-diameter ratio plane metal microneedle array

A technology with a large aspect ratio and microneedle arrays, applied in the field of medical devices, can solve the problems of difficult mass production, complicated manufacturing process, and high cost, and achieve the effects of cost reduction, low cost, and improved efficiency

Active Publication Date: 2019-08-23
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, the manufacturing process is ingeniously designed and can successfully prepare metal microneedles with a large aspect ratio, but relatively speaking, the manufacturing process is more complicated, the cost is higher, and it is difficult to produce in batches
In addition, how to ensure that the microneedle array composed of columnar microneedles with large aspect ratio does not buckle or break when piercing the skin has not yet been effectively solved.

Method used

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  • Large length-diameter ratio plane metal microneedle array, preparation method and clamping and penetration auxiliary devices of large length-diameter ratio plane metal microneedle array

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specific Embodiment

[0052] The technical solution of the present invention will be described in detail below in conjunction with the accompanying drawings. The present invention processes metal microneedle arrays in batches at one time, and the ideal total cutting thickness of wire cutting is 2 cm. For example, the overall wall thickness of the tooling is 5 mm, the depth of the groove is 2 mm, and the thickness of each metal sheet is 100 microns. The number of microneedles that can be cut at one time is 140 pieces, and compared with other microneedle processing methods, the efficiency is greatly improved. In addition, the cost of wire cutting processing technology is relatively low, so the microneedle array processing method provided by the present invention has low cost. After the clamping tool is used, except that the material at the path of the cutting wire is cut off, other parts remain intact, which can improve efficiency and reduce costs. The clamping tool compacts multiple sheets of metal ...

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Abstract

The invention discloses a large length-diameter ratio plane metal microneedle array, a preparation method and clamping and penetration auxiliary devices of the large length-diameter ratio plane metalmicroneedle array, and belongs to the technical field of medical instruments. A large-sized metal sheet is cut into small-sized metal sheets; a clamping tool consisting of an upper metal cover plate and a lower metal cover plate is machined, wherein the inner sides of the upper metal cover plate and the lower metal cover plate of the clamping tool are provided with grooves, and the metal sheets are placed in the grooves and fastened through bolts; and the geometric shape and the size of the microneedle array are designed, and linear cutting is performed on the tool and the metal sheets as a whole to obtain the plane metal microneedle array with a plurality of microneedle bodies. In addition, the invention also provides the assembly clamping device and the penetration auxiliary device of the large-aspect-ratio plane metal microneedle array. The assembled penetration auxiliary device is placed on the skin, and the microneedle array penetrates into the skin through the auxiliary device. The microneedle array can be manufactured in large batches through simple assembly, the cost is low, the efficiency is high, and the processing precision of microneedle tips can be guaranteed; and moreover, the use reliability of large length-diameter ratio microneedles can be comprehensively improved.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and relates to a planar metal microneedle array with a large aspect ratio, a preparation method and a clamping and piercing auxiliary device. Background technique [0002] Microneedle (MN) generally refers to a microneedle with a length of tens of microns to several millimeters and a tip diameter of less than tens of microns. Microneedles are used to puncture the stratum corneum of the skin, thereby breaking through the biological barrier of the stratum corneum of the skin, and forming micron-scale drug delivery channels on the surface of the skin. Type and range of drugs. In addition, due to the small size of the microneedle, the trauma and pain caused when the skin is punctured are very small, which not only does not cause obvious discomfort to the patient receiving the medicine, but also helps prevent infection and is more conducive to wound recovery. Because of the many advantages m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B23P15/00A61M37/00
CPCA61M37/0015A61M2037/0023A61M2037/0053B23P15/00
Inventor 马国军吴承伟安小龙韩啸张伟吕永涛马建立
Owner DALIAN UNIV OF TECH
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