Photo-thermal nano medicine-carrying system based on cantharidin temperature-sensitive liposomes and gold nanoparticles

Abstract

The invention relates to a photo-thermal nano medicine-carrying system based on cantharidin temperature-sensitive liposomes and gold nanoparticles. The system comprises the cantharidin temperature-sensitive liposomes and the gold nanoparticles. The cantharidin temperature-sensitive liposomes are composed of multiple lipids at different phase conversion temperatures, cantharidin is wrapped by the cantharidin temperature-sensitive liposomes, and the gold nanoparticles cover the surfaces of the cantharidin temperature-sensitive liposomes to form nano gold shell layers and have a plasma resonancepeak of 530-800 nanometers; the nano gold shell layers wrapping the surfaces of the liposomes have a plasma absorption characteristic and a photo-thermal conversion characteristic in a near-infrared absorption window of the tissue at 800 nanometers; the nano gold shell layers generate a photothermy under irradiation of a near-infrared laser of 808 nanometers, so that the cores of the internal temperature-sensitive liposomes are fractured, the liposomes are decomposed into the gold nanoparticles, with the particle diameters about 5 nanometers, discharged through the liver and kidney function again, the cantharidin wrapped by the cores of the liposomes can also be controlled to be released in cytoplasm of tumor cells, the thermal shock reaction of the tumor cells is inhibited, and accordingly the photothermy and particularly the tumor inhibition effect at low-intensity illumination are improved.

Description

technical field [0001] The invention relates to the field of antitumor drug research, in particular to a photothermal nano-drug loading system based on cantharidin thermosensitive liposomes and gold nanoparticles. Background technique [0002] At present, the treatment of tumors is mainly based on surgery, supplemented by radiotherapy, chemotherapy and other drug treatments. However, it is difficult to completely remove the tumor tissue by surgical methods, and there are problems such as toxic and side effects and multi-drug resistance of tumor tissue to drugs in the auxiliary drug therapy. The use of new technologies to improve the efficacy of existing tumor treatments is a major problem to be solved in the field of public health in my country. Photothermal therapy provides another way for tumor treatment. It can use a medium with high photothermal conversion rate to convert light energy into heat energy, heat the lesion to make the temperature reach the critical therapeut...

AI Technical Summary

Problems solved by technology

However, the in vivo toxicity and metabolic pathways of these photothermal nanomaterials are not very clear at present, and the complete in vivo clearance of nanomaterials must ensure that the particles are <5.5nm and can be excreted through the glomerular basement membrane.

On the other hand, gold nanoparticles with small particle size exist in the blood circulation for a short time and are easily cleared by the endothelial reticular system, so they are not suitable as a medium for photothermal therapy of tumors in vivo.

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