Drug-loaded nano-composite, preparation method thereof and application of nano-composite
A drug-loaded nano-composite technology, applied in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve the problem of solubility, the mechanism of metabolic toxicity of tumors is not fully researched, the drug damages normal organs, and increases the metabolic burden. and other problems to achieve the effect of improving load stability, avoiding metabolic burden and stable release
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Embodiment 1
[0087] This embodiment provides a drug-loaded nanocomposite, the preparation method of which specifically includes the following steps:
[0088] (1) 20mg PEG-co-PLGA was dissolved in 4mL dichloromethane to obtain solution A;
[0089] (2) 0.4mg of Gd@C 82 (OH) 22 Dissolve in 400 μL of secondary water to obtain solution B;
[0090] (3) Mix solution B obtained in step (2) with 0.4 mg of doxorubicin hydrochloride, and stir for 24 hours at room temperature in the dark to obtain solution C;
[0091] (4) Mix solution A obtained in step (1) with solution C obtained in step (3) under magnetic stirring, and ultrasonically emulsify for 2 minutes at a power of 50 W with an ultrasonic breaker to obtain colostrum;
[0092] (5) Add 6mL emulsifier to the colostrum that step (4) obtains, obtain double emulsion after ultrasonic breaker 10min under the power of 100W with ultrasonic breaker; , and then centrifuged at a high speed to obtain the drug-loaded nanocomposite.
Embodiment 2
[0094] This embodiment provides a drug-loaded nanocomposite, the preparation method of which specifically includes the following steps:
[0095] (1) 30mg PEG-co-PLGA was dissolved in 4mL dichloromethane to obtain solution A;
[0096] (2) 0.6mg of Gd@C 82 (OH) 22 Dissolve in 400 μL of secondary water to obtain solution B;
[0097] (3) Mix solution B obtained in step (2) with 0.8 mg of doxorubicin hydrochloride, and stir for 24 hours at room temperature in the dark to obtain solution C;
[0098] (4) Mix solution A obtained in step (1) with solution C obtained in step (3) under magnetic stirring, and ultrasonically emulsify for 1 min at a power of 75W with an ultrasonic breaker to obtain colostrum;
[0099] (5) Add 9mL emulsifier to the colostrum that step (4) obtains, obtain double emulsion after ultrasonic breaker 7min under the power of 200W with ultrasonic breaker; , and then centrifuged at a high speed to obtain the drug-loaded nanocomposite.
Embodiment 3
[0101] This embodiment provides a drug-loaded nanocomposite, the preparation method of which specifically includes the following steps:
[0102] (1) 50mg PEG-co-PLGA was dissolved in 4mL dichloromethane to obtain solution A;
[0103] (2) 1 mg of Gd@C 82 (OH) 22 Dissolve in 400 μL of secondary water to obtain solution B;
[0104] (3) Mix solution B obtained in step (2) with 3 mg of doxorubicin hydrochloride, and stir for 24 hours at room temperature in the dark to obtain solution C;
[0105] (4) Mix solution A obtained in step (1) with solution C obtained in step (3) under magnetic stirring, and ultrasonically emulsify for 5 minutes at a power of 100 W with an ultrasonic breaker to obtain colostrum;
[0106] (5) Add 15mL emulsifier to the colostrum that step (4) obtains, and obtain double emulsion after ultrasonic breaking under the power of 500W with an ultrasonic breaker for 10min; the double emulsion obtains a dispersion after rotary steaming under reduced pressure at roo...
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