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Kit used for tumor exosome nanometer fluorescence detection and application of kit

A tumor exosome and nano-fluorescence technology, which is applied in the field of "Turn-on" tumor exosome nano-fluorescence detection kits, can solve the problems of complicated prostate cancer operation, weak anti-interference, and long time consumption, and achieve good results. The effect of anti-interference ability and large clinical application potential

Active Publication Date: 2019-08-02
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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Problems solved by technology

[0005] In view of the shortcomings of the prior art described above, the purpose of the present invention is to provide a tumor exosome nano-fluorescent detection kit, which is used to solve the problem of complex operation, time-consuming and anti-interference of the detection method for prostate cancer in the prior art. Weakness and other issues

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  • Kit used for tumor exosome nanometer fluorescence detection and application of kit
  • Kit used for tumor exosome nanometer fluorescence detection and application of kit
  • Kit used for tumor exosome nanometer fluorescence detection and application of kit

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[0039] Embodiments of the present invention are described below through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific implementation modes, and various modifications or changes can be made to the details in this specification based on different viewpoints and applications without departing from the spirit of the present invention.

[0040] The present invention intends to use Prostate Specific Membrane Antigen (PSMA) nucleic acid aptamer (aptamer) to specifically recognize prostate cancer PSMA(+) exosome subpopulation, aggregation-induced luminescent molecule TPE-TA fluorescent reporter group Together with graphene oxide (Graphene Oxide, GO) fluorescence quenching group to form a label-free "Turn-on" fluorescent reporter system, and to construct a nano-fluorescenc...

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Abstract

The invention discloses a kit used for tumor exosome nanometer fluorescence detection and application of the kit. The kit comprises an identification element, a fluorescence reporter group and a fluorescence quenching group. The kit and the application thereof not only confirm that the PSMA on the human plasma source exosome can be used as a biomarker for identifying a health volunteer and a prostate cancer patient but further proves that the influence of normal cell source exosome in a clinical plasma specimen on a detection result can be effectively avoided through the method, and the kit has good anti-interference capability and a relatively large clinical application potential in the aspect of prostate cancer PSMA(+) exosome subgroup analysis.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a "Turn-on" tumor exosome nano-fluorescence detection kit based on nucleic acid aptamers and aggregation-induced luminescent materials and its application. Background technique [0002] In recent years, the incidence of prostate cancer in my country has been increasing year by year. The proportion of newly diagnosed patients in most regions is higher than that in Europe and the United States. Prostate cancer has the characteristics of rapid development and easy metastasis. Timely diagnosis and treatment before symptoms and signs appear can significantly Improve prognosis and prolong patient survival. Therefore, it is particularly important to establish sensitive, specific, non-invasive, convenient and rapid detection methods for early screening, diagnosis or monitoring of prostate cancer to control the development of prostate cancer and improve the quality of life of patients. [000...

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Application Information

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IPC IPC(8): G01N33/574G01N33/53
CPCG01N33/57434G01N33/5308
Inventor 郑磊李博潘炜伦刘春辰司徒博张晔安泰学张涵
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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