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Doxycycline hydrochloride soluble powder and preparation method thereof

A doxycycline hydrochloride, soluble technology, applied in the directions of tetracycline active ingredients, powder delivery, pharmaceutical formulations, etc., can solve the problems of reduced effective content of doxycycline hydrochloride, poor stability, failure, etc., to improve efficacy and palatability. Good performance and the effect of increasing utilization

Inactive Publication Date: 2019-08-02
河南健恒动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems in the prior art that the effective content of doxycycline hydrochloride is reduced or even ineffective due to factors such as poor self-stability, easy hydrolysis, and easy oxidative decomposition when exposed to light and heat, the present invention provides a doxycycline hydrochloride soluble powder and its preparation method

Method used

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  • Doxycycline hydrochloride soluble powder and preparation method thereof
  • Doxycycline hydrochloride soluble powder and preparation method thereof
  • Doxycycline hydrochloride soluble powder and preparation method thereof

Examples

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Embodiment

[0028] (1) Weigh according to the mass percentage of each component shown in Examples 1-4 in Table 1, and dissolve the slow-release agent with ethanol to obtain solution A;

[0029] (2) Dissolving the doxycycline hydrochloride in water, adding the metal complexing agent, the antioxidant, and the solution A while stirring, and mixing uniformly to obtain the solution B;

[0030] (3) spray drying the solution B to obtain powder;

[0031] (4) Mix the powder and the anhydrous glucose evenly, and pass through an 80-mesh sieve to obtain the doxycycline hydrochloride soluble powder.

[0032] The ratio of each component of the doxycycline hydrochloride soluble powder of table 1 embodiment 1-4

[0033]

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PUM

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Abstract

The invention provides doxycycline hydrochloride soluble powder. Based on the total mass of various components being 100%, the doxycycline hydrochloride soluble powder is prepared from the following components in percentage by mass: 10% of doxycycline hydrochloride, 28-34% of sustained-release agent, 1-3% of complexing agent, 4-9% of antioxidant, and the balance of anhydrous dextrose. The stability of the doxycycline hydrochloride soluble powder is relatively high, the effective content of the doxycycline hydrochloride is slowly lowered, and the drug failure time is effectively prolonged.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a doxycycline hydrochloride soluble powder and a preparation method thereof. Background technique [0002] Doxycycline hydrochloride, also known as doxycycline, its properties are light yellow or yellow crystalline powder, smelly, bitter, soluble in water or methanol, slightly soluble in ethanol or acetone, insoluble in chloroform. Doxycycline hydrochloride is the second generation of semi-synthetic tetracycline derivatives. It is an excellent spectrum antibiotic for veterinary use against Gram-negative bacteria, Gram-positive bacteria, spirochetes, rickettsia, Mycoplasma and other pathogenic bacteria have a strong inhibitory effect, and are widely used in the treatment of livestock and poultry bacterial diseases caused by sensitive bacteria, mainly for the treatment of respiratory tract, urinary tract and biliary tract infections caused by sensitive bacter...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/38A61K47/20A61K47/12A61K47/18A61K47/22A61K31/65A61P31/04A61P11/00
CPCA61K9/145A61K9/146A61K31/65A61P11/00A61P31/04
Inventor 朱红标王申锋赵文刚
Owner 河南健恒动物药业有限公司
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