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Anti-coccidial Chinese medicine compound and application thereof

An anti-coccidial and traditional Chinese medicine technology, applied in anti-infective drugs, pharmaceutical formulations, drug combinations, etc., can solve problems such as no reports in research, and achieve the effects of reducing animal death, reducing bacterial secondary infection, and ensuring quality and safety.

Inactive Publication Date: 2019-07-26
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been many reports on the prevention and treatment of coccidiosis with traditional Chinese medicine compound prescriptions, there are no reports on the research on the prevention and treatment of coccidiosis in livestock and poultry after combining two kinds of traditional Chinese medicine extracts, Changshan alkaloid and Sophora flavescens alkaloid

Method used

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  • Anti-coccidial Chinese medicine compound and application thereof
  • Anti-coccidial Chinese medicine compound and application thereof
  • Anti-coccidial Chinese medicine compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The weight addition amount of the Chinese medicine compound in the feed is 0.05% (0.5kg / ton of feed).

[0020] Case 1: In August 2017, a Rex rabbit farm in Bayannaoer City, Inner Mongolia, 4 weeks old, had a total of 500 rabbits, of which 126 became ill (12 died). The sick rabbits were depressed, severe diarrhea, neurological symptoms appeared in the later stage, the head was thrown back, the limbs twitched, screamed, and finally died. Anatomy found that the dead rabbits had flatulence, hepatomegaly, and blood vessels and mucous membranes in the intestinal walls of the duodenum, jejunum, and ileum were congested. Microscopic examination of feces found a large number of coccidiosis oocysts, and the diagnosis was rabbit coccidiosis. After communicating with the animal owners, all the remaining diseased rabbits (114) were used for the test, and were randomly divided into the Chinese medicine compound group and the dichlorothiazide group. The results showed that after 3-4...

Embodiment 2

[0024] The weight addition amount of the Chinese medicine compound in the feed is 0.03% (0.3kg / ton of feed).

[0025] Case 2: In September 2018, a meat duck farm in Tianshui City, Gansu Province, 15 days old, had a total of 600 ducks, of which 132 became ill. The sick duck had depression, loss of appetite, and bloody diarrhea; the autopsy found that the dead duck had swollen duodenum, enlarged mesenteric lymph nodes, and a large number of bleeding points; a large number of coccidiosis oocysts were found in the stool microscope, and it was diagnosed as duck coccidiosis. After communicating with the livestock owners, all the sick ducks were used for the experiment, and were randomly divided into the Chinese medicine compound group, the Baiqiuqing group and the chicken coccidia powder group, and the rest of the healthy ducks were drinking Baiqiuqing for 2 days for prevention. The results showed that after 2-3 days of administration, the clinical symptoms of the test ducks in each...

Embodiment 3

[0029] The weight addition amount of the Chinese medicine compound in the feed is 0.02% (0.2kg / ton of feed).

[0030] Case 3: In July 2018, a laying hen farm in Yongdeng County, Gansu Province, 35 days old, had a total of 2,000 chickens in stock, and 350 of them became ill. The sick chicken was depressed, the feathers were disheveled, the desire to eat decreased, and a large amount of bloody stool was discharged; the cecum and duodenum of the dead chicken were found to be severely swollen, and there were bloody contents; a large number of coccidia oocysts were found in the stool microscope, and the diagnosis was chicken coccidia sick. After the consent of the animal owner, all the sick chickens were used for the experiment, and were randomly divided into the Chinese medicine compound group, the dichlorothiazide group and the chicken coccidia powder group, and the remaining healthy chickens were given dichlorothiazide for 2 days of continuous drinking water for prevention. The...

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Abstract

The invention discloses an anti-coccidial Chinese medicine compound composed of an antifeverile dichroa root alkaloid and a radix sophorae flavescentis alkaloid and provides application thereof. The Chinese medicine compound effectively integrates good anti-coccidial activity of the antifeverile dichroa root alkaloid and good antibacterial activity of the radix sophorae flavescentis alkaloid, andbacterial secondary infection and animal death caused by coccidiosis are remarkably reduced. The two alkaloids in the compound belong to Chinese medicine extracts, which is favorable for full absorption and utilization of an animal body, and an anti-coccidial medicinal effect of the medicine can be maximized. Only two Chinese medicine extracts exist in the compound, the quality standard is easy tocontrol in and use, and the product quality safety can be ensured.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to an anti-coccidial traditional Chinese medicine compound and its application. Background technique [0002] Coccidiosis is a parasitic disease that seriously threatens the life and health of livestock and poultry. The annual economic loss in my country is as high as 3 billion yuan, of which the cost of anticoccidial drugs is about 600 million yuan. Coccidia infection leads to hematochezia and decreased immunity of animals, and the subsequent bacterial infection is one of the main reasons for the sharp increase in livestock mortality and the difficulty of drug control. At present, the anticoccidial drugs mainly include: ① chemical drugs, such as toltrazuril, hemosanone, sulfonamides, etc., which have serious drug resistance and drug residues; , almost every compound contains Changshan, but because the physiological structure of poultry is different from th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K31/517A61K31/4375A61P33/02A61K36/185
CPCA61K31/4375A61K31/517A61K36/185A61K36/489A61P33/02A61K2300/00
Inventor 郭志廷王玲熊琳罗晓琴徐海城尚若峰郝宝成杨珍
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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