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Sorbent for dialysis device and dialysis system

An adsorbent, dialysate technology, used in dialysis systems, selective adsorption, ion exchange treatment devices, etc., can solve problems such as defects, low toxin removal levels, and rare pH evolution.

Active Publication Date: 2019-07-23
TEMASEK POLYTECHNIC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The major disadvantages of CAPD include: low levels of toxin removal; the need for constant replacement of used dialysate, which may interfere with the patient's daily activities
However, this practice rarely leads to an acceptable pH evolution, albeit at the cost of a large release of sodium
Consequently, most dialysis compositions used in dialysis are deficient, or may even be harmful to the patient

Method used

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  • Sorbent for dialysis device and dialysis system
  • Sorbent for dialysis device and dialysis system
  • Sorbent for dialysis device and dialysis system

Examples

Experimental program
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preparation example Construction

[0114] The present invention also provides a method for preparing an adsorbent, comprising: combining immobilized uremic toxin-treating enzyme particles for converting urea into ammonium ions with an ammonium ion mainly exchanged for hydrogen ions and an essential cation mainly exchanged for sodium ions. cation exchange particles; providing a source of sodium; and optionally, mixing in anion exchange particles and / or organic compound adsorption particles.

[0115] In one embodiment, the sorbent is contained in at least one sorption cartridge. The sorption cartridge can be configured for easy removal from the dialysis device. The cartridges are available in a compact design and are made of wear-resistant materials. The cartridge can be made of chemically and biologically inert elastic material. The adsorption cartridge may also have the ability to withstand the pressure of the fluid flow system in the dialysis device without leakage. The cartridge can be made of materials ca...

Embodiment 1

[0139] Embodiment 1: the preparation of zirconium phosphate

[0140] Zirconium phosphate is synthesized by existing methods, for example, according to the US Patent No. US3850835, by reacting an aqueous mixture of basic zirconium sulfate and phosphoric acid, or by carbonic acid Reaction synthesis of sodium zirconium and aqueous mixtures of phosphoric acid.

[0141] The resulting product was titrated to pH 4.5. Wherein, 5M sodium hydroxide solution is gradually added to the aqueous slurry of zirconium phosphate until the pH value reaches 4.5. After titration, the zirconium phosphate was first washed until the filtrate was within the acceptable leachable range and then air dried.

Embodiment 2

[0142] Embodiment 2: the preparation of hydrated zirconia

[0143]Hydrated zirconia is synthesized by existing methods, for example, by reacting an aqueous mixture of sodium zirconium carbonate and sodium hydroxide according to the method described in US Patent No. US4256718. After the hydrous zirconia is synthesized, the resulting product is titrated to a pH of 12 to 13. Wherein, an aqueous slurry of hydrated zirconia can be prepared and titrated with 5M sodium hydroxide until the pH value of the slurry reaches 12-13. In some cases, the hydrated zirconia is also washed until the leachate concentration in the filtrate is within acceptable levels, and then it is air dried. Alternatively, the hydrated zirconia can be recovered directly from the slurry and air dried. The hydrated zirconia that has undergone the washing step is called "washed hydrated zirconia", and the hydrated zirconia recovered directly from the titration slurry is called "unwashed hydrated zirconia".

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PUM

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Abstract

The invention relates to a sorbent for removing metabolic waste products from a dialysis liquid, the sorbent comprising a soluble source of sodium ions. The sorbent comprises an ion exchange system which converts urea to ammonium ions and which is configured to exchange ammonium ions for predominantly hydrogen ions and to exchange Ca, Mg, and K for predominantly sodium ions. The soluble source ofsodium ions overcomes an initial drop in sodium concentration in regenerated dialysate. When used in conjunction with an infusion system configured to utilise exchange of Ca, Mg and K for sodium during dialysate regeneration a desired sodium ion concentration can be maintained.

Description

technical field [0001] The present invention relates to an adsorbent for dialysis and an adsorption system for regenerative dialysis which may be, but not limited to, hemodialysis, peritoneal dialysis, liver dialysis, lung dialysis, purification of water and regeneration of biological fluids . Background technique [0002] Even if an apparently prior published document is cited or discussed in this specification, it should not be taken as an acknowledgment that the document is part of the state of the art or is common general knowledge. [0003] Dialysis is the separation of particles by utilizing the difference in the ability of particles in a liquid to pass through a membrane. In medicine, the term refers to the clinical purification of blood as a substitute for normal renal function. Dialysis is used especially as a replacement for kidney function in patients with renal dysfunction or kidney failure. The term can also refer to the purification of other biological fluid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/16B01J47/04B01J39/12B01J41/10B01J20/20B01J47/024
CPCA61M1/1696B01J39/12B01J41/10B01J47/024B01J47/04B01J20/20B01J2220/42B01J2220/46B01J2220/62A61M1/3623A61M2202/0057B01D15/08B01J20/0211B01J39/17B01J20/24A61M2205/02A61M1/1656A61M1/1654A61M1/14
Inventor 克里斯丁·葛特·布吕歇尔彼得·海伍德
Owner TEMASEK POLYTECHNIC
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