Production raw material of thiabendazole and preparation technology of production raw material

A preparation process, the technology of thiabendazole, applied in the direction of organic chemistry, etc., can solve the problems of excessive pH value adjustment, affecting product conversion rate and quality, and insufficient raw material ratio, so as to ensure the pH value and quality assurance Effect

Inactive Publication Date: 2019-07-23
孟宪锋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above scheme improves the time and conversion rate, the proportioning of raw materials is not fine enough, especially in the proportioning of lactic acid and o-phenylenediamine. Meanwhile, in the production process, the range of pH value adjustment is too large, This in turn affects the conversion rate and quality of the final product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A raw material for the production of thiabendazole, mainly including lactic acid, o-phenylenediamine, acetone, inorganic acid, potassium permanganate, bromine, ethyl acetate, formamide and phosphorus pentasulfide; wherein, the lactic acid and o-phenylenediamine The molar ratio is 1:1.17; the ratio of ethyl acetate, formamide and phosphorus pentasulfide is 2:1:1.

[0023] Concrete preparation process is as follows:

[0024] (1) Divide the lactic acid and o-phenylenediamine mixed in proportion into multiple parts, add them to different reaction containers, and carry out condensation reaction with equal parts of hydrochloric acid aqueous solution. pH value, and remove the 2-α-hydroxyethylbenzimidazole obtained in the container with the maximum and minimum pH value, and keep the 2-α-hydroxyethylbenzene obtained in the remaining containers;

[0025] (2) Multiple parts of 2-α-hydroxyethylbenzimidazole obtained in step (1) were filtered and dried several times, and finally mi...

Embodiment 2

[0030] A raw material for the production of thiabendazole, mainly including lactic acid, o-phenylenediamine, acetone, inorganic acid, potassium permanganate, bromine, ethyl acetate, formamide and phosphorus pentasulfide; wherein, the lactic acid and o-phenylenediamine The molar ratio is 1:1.17; the ratio of ethyl acetate, formamide and phosphorus pentasulfide is 2:1:1.

[0031] Concrete preparation process is as follows:

[0032] (1) Divide the mixed lactic acid and o-phenylenediamine into multiple parts, add them to different reaction containers, and carry out condensation reaction with equal parts of hydrochloric acid aqueous solution. After the reaction is completed, adjust the pH in different containers respectively value, and remove the 2-α-hydroxyethylbenzimidazole obtained in the container with the pH value maximum and minimum value, and keep the 2-α-hydroxyethylbenzene obtained in the remaining containers;

[0033] (2) Multiple parts of 2-α-hydroxyethylbenzimidazole o...

Embodiment 3

[0038] A raw material for the production of thiabendazole, mainly including lactic acid, o-phenylenediamine, acetone, inorganic acid, potassium permanganate, chlorine, ethyl acetate, formamide and phosphorus pentasulfide; wherein, the lactic acid and o-phenylenediamine The molar ratio is 1:1.17; the ratio of ethyl acetate, formamide and phosphorus pentasulfide is 2:1:1.

[0039] Concrete preparation process is as follows:

[0040] (1) Divide the mixed lactic acid and o-phenylenediamine into multiple parts, add them to different reaction containers, and carry out condensation reaction with equal parts of hydrochloric acid aqueous solution. After the reaction is completed, adjust the pH in different containers respectively value, and remove the 2-α-hydroxyethylbenzimidazole obtained in the container with the pH value maximum and minimum value, and keep the 2-α-hydroxyethylbenzene obtained in the remaining containers;

[0041] (2) Multiple parts of 2-α-hydroxyethylbenzimidazole ...

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PUM

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Abstract

The invention provides a production raw material of thiabendazole. The production raw material mainly comprises components as follows: lactic acid, o-phenylenediamine, acetone, inorganic acid, potassium permanganate, bromine, ethyl acetate, formamide and phosphorus pentasulfide, wherein the mole ratio of lactic acid to o-phenylenediamine is 1:1.17; the ratio of ethyl acetate, formamide and phosphorus pentasulfide is 2:1:1. The raw material ratio is sophisticated, the adjusting range of PH value is narrowed in a preparation process, the conversation rate of a product is increased, and the quality of the product is improved.

Description

technical field [0001] The invention relates to a process of thiabendazole, in particular to a raw material for the production of thiabendazole and a preparation process thereof, belonging to the technical field of agricultural production. Background technique [0002] Thiabendazole is commonly known as Teketol, Tibendazole, Thiobenazole, Thiabendazole, and Thiabendazole. It has the ability to conduct systemically to the apex, but not to the base. Long-lasting, cross-resistance with benzimidazole fungicides. It has inhibitory activity on Ascomycetes, Basidiomycetes and Deuteromycetes, and is used to prevent and control fungal diseases of various crops and preserve fresh fruits and vegetables. It is a high-efficiency, broad-spectrum, international general-purpose fungicide. It is used for processing 42% thiabendazole suspension concentrate, 60% thiabendazole wettable powder, 3% thiabendazole smoke agent, fruit fresh-keeping paper, etc. Prevention and treatment of various di...

Claims

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Application Information

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IPC IPC(8): C07D417/04C07D235/26
CPCC07D417/04C07D235/26
Inventor 孟宪锋
Owner 孟宪锋
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