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A kind of preparation method of surface enhanced Raman test paper

A surface-enhanced Raman and test paper technology, which is applied in Raman scattering, instruments, liquid chemical plating, etc., can solve the problems of uneven signal enhancement effect and large difference in signal intensity of flexible surface-enhanced Raman substrates, and achieve good Raman Man enhancement effect, strong signal, and sensitivity-enhancing effect

Active Publication Date: 2021-09-24
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the current method of preparing flexible surface-enhanced Raman substrates, random strong reducing agents are often used to react with noble metal ions, and it is difficult to form noble metal particles with controllable morphology and uniform distribution on the surface of flexible substrates, which leads to the enhancement of flexible surfaces. The signal enhancement effect of the Raman substrate is not uniform, and the signal intensity obtained in different regions varies greatly, which has limitations in the application field of quantitative analysis

Method used

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  • A kind of preparation method of surface enhanced Raman test paper
  • A kind of preparation method of surface enhanced Raman test paper
  • A kind of preparation method of surface enhanced Raman test paper

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Embodiment 1

[0041] In the present embodiment, the preparation method of surface-enhanced Raman test paper is as follows:

[0042] (1) with Ti 3 AlC 2 The powder is used as a precursor, soaked to 9mol L -1 In the mixed solution of HCl and LiF (in the mixed solution of HCl and LiF, the molar ratio of HCl and LiF is 4.7:1), Ti is selectively etched away by the mild method of in-situ generation of HF by HCl and LiF 3 AlC 2 Al atomic layer to get Ti 3 C 2 T x Two-dimensional layer, wash it with deionized water, filter it with suction; then Ti 3 C 2 T x The slurry is dispersed in deionized water, shaken or ultrasonicated, and then centrifuged, and the upper liquid is ultra-thin two-dimensional Ti 3 C 2 T x Nanosheet suspension, Ti 3 C 2 T x The thickness of the nanosheets is about 1nm;

[0043] (2) the above prepared Ti 3 C 2 T x Nanosheet suspension was vacuum filtered into flexible Ti 3 C 2 T x Membrane, air dry, Ti 3 C 2 T x The thickness of the film is 20 μm;

[004...

Embodiment 2

[0053] In this embodiment, the difference from embodiment 1 is:

[0054] HAuCl in step (3) 4 The concentration is 0.1mmol·L -1 , and then drop 10 μL of the above solution on Ti 3 C 2 T x film, and nano-gold is generated on the surface of the substrate to obtain a flexible surface-enhanced Raman substrate.

[0055] like Figure 7 As shown in the transmission electron microscope picture of the surface-enhanced Raman test paper described in this embodiment, the gold nanoparticles are spherical.

[0056] like Figure 8 As shown, the surface-enhanced Raman test paper described in this embodiment is used for the detection of the Raman signal of methylene blue detection. Depend on Figure 8 It can be seen that the test paper has high Raman activity and resolution.

Embodiment 3

[0058] In this embodiment, the difference from embodiment 1 is:

[0059] 1mmol L in step (3) -1 H 2 PdCl 4 solution, and then drop 10 μL of the above solution on Ti 3 C 2 T x film, and generate nano-palladium on the surface of the substrate to obtain a flexible surface-enhanced Raman substrate.

[0060] like Figure 9 As shown in the transmission electron microscope picture of the surface-enhanced Raman test paper described in this embodiment, the palladium nanoparticles are spherical.

[0061] like Figure 10 As shown, the surface-enhanced Raman test paper described in this embodiment is used for the detection of the Raman signal of methylene blue detection. Depend on Figure 10 It can be seen that the test paper has excellent Raman activity and sensitivity.

[0062] like Figure 11 As shown, the Raman surface scan of the surface-enhanced Raman test paper prepared in this example to detect trace amounts of the dye methylene blue shows the uniformity of the enhancem...

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Abstract

The invention relates to the technical field of surface-enhanced Raman scattering, in particular to a method for preparing a surface-enhanced Raman test paper. The method prepares precious metal particles and Ti 3 C 2 T x Miconene composite film, and used for surface-enhanced Raman substrate materials. The present invention utilizes Ti 3 C 2 T x Miconene can undergo oxidation-reduction reaction with noble metal solution, drop a certain concentration of noble metal solution onto the flexible Ti 3 C 2 T x A layer of uniform, complete and dense noble metal particles can be generated in situ on the surface of the Micon film, and the surface-enhanced Raman test paper thus obtained has good Raman enhancement effect, excellent reproducibility and ultra-long The shelf life is long, and the preparation process is simple and easy to operate. Therefore, the surface-enhanced Raman test paper with high stability and good reproducibility provided by the present invention can be applied to the detection of trace harmful substances, biomarkers, pathogenic bacteria or viruses, etc., and has broad application prospects.

Description

technical field [0001] The invention relates to the technical field of surface-enhanced Raman scattering, in particular to a preparation method of surface-enhanced Raman test paper. Background technique [0002] Surface-enhanced Raman spectroscopy (SERS) refers to the phenomenon that the Raman signal of the target molecule can be greatly enhanced when the target molecule is adsorbed on the surface of certain metal (such as: gold, silver, copper, etc.) particles. In recent years, surface-enhanced Raman spectroscopy, as a method of trace or ultra-trace analysis and detection, has received extensive attention in many fields such as food safety, environmental monitoring, and biomedicine. Surface-enhanced Raman substrates are the prerequisite for obtaining surface-enhanced Raman signals. In order to make surface-enhanced Raman technology a routine detection method for large-scale applications, the prepared surface-enhanced Raman substrates should have high sensitivity, good enhan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65C23C18/42B82Y40/00
CPCB82Y40/00C23C18/42G01N21/658
Inventor 王晓辉程仁飞胡敏敏张超
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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