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A kind of insect-specific small molecule toxin and its application

A small-molecule, specific technology, applied in applications, insecticides, organic chemistry, etc., to achieve strong effects, strong insect selective toxicity, and reliable results

Active Publication Date: 2022-04-15
HUNAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, there is no report on the selective effect of these acetylpolyamine small molecules on insect sodium channels

Method used

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  • A kind of insect-specific small molecule toxin and its application
  • A kind of insect-specific small molecule toxin and its application
  • A kind of insect-specific small molecule toxin and its application

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Embodiment Construction

[0029] The invention provides an insect-specific small-molecule toxin, which is a quaternary ammonium-type small-molecule toxin isolated and purified from the crude venom of E. grandina. The relative molecular weight is 674.4647. The nuclear magnetic resonance structure analyzes The molecular formula of the specific small molecule toxin is C 33 h 59 o 5 N 10 , whose structural formula is:

[0030]

[0031] The application of the insect-specific small molecule toxin provided by the present invention in insecticides or in neurobiological reagents and / or medicines, especially when it is used as an insecticide in the manner of blocking or completely blocking insect sodium ion channels application. When the insect-specific small-molecule toxin completely blocks the insect sodium ion channel, the concentration of the insect-specific small-molecule toxin is not more than 10 μmol / L; the half-effective concentration of the insect-specific small-molecule toxin on the insect sodiu...

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Abstract

The invention belongs to the technical field of chemistry and chemical engineering, and relates to an insect-specific small-molecule toxin and its application. The insect-specific small-molecule toxin is a quaternary ammonium-type small-molecule toxin separated and purified from the crude venom of E. grandis, with a relative molecular weight of 674.4647 , NMR structure analysis, the molecular formula of the small molecular toxin isolated and purified from the crude venom of E. grandis is C 33 h 59 o 5 N 10 , the present invention provides an insect-specific small molecule toxin with selective activity on insects, less affected by pH, stronger effect and more stable effect and its application.

Description

technical field [0001] The invention belongs to the technical field of chemistry and chemical engineering, and relates to a small molecule toxin and its application, in particular to an insect-specific small molecule toxin and its application. Background technique [0002] The large-bellied garden spider (Araneus ventricosus) is a medium-sized spider that feeds on insects, and belongs to the phylum Arthropoda, Araneus, Aranea, Orbidae, and Orb genus in classification. The arachnid is one of the most widely distributed spiders in the world, and its venom contains a large number of toxic components that can anesthetize or kill insects. Explore the structural and functional characteristics of these insect-specific small molecule toxins, and screen out precursor molecules that may be used as neurobiological research tool reagents, drugs and insecticides. At present, there are very few studies on the venom of the lobster spider. Kawai et al. in Japan found that the extract of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D209/18A01N47/44A01P7/04
CPCC07D209/18A01N47/44
Inventor 段志贵刘凯
Owner HUNAN NORMAL UNIVERSITY
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