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Gel composition, patch and application thereof

A gel composition and patch technology, which can be used in compound screening/testing, preparations for in vivo tests, pharmaceutical formulations, etc., can solve problems such as unstable results of antagonizing and stimulating patches

Active Publication Date: 2022-02-11
三立慧评(北京)检测技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the deficiencies of the prior art, the present invention provides a gel composition, which can solve the problem of unstable patch results of antagonizing stimulation when used in patch products, and reduce misjudgment of results due to unstable modeling of stimuli

Method used

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  • Gel composition, patch and application thereof
  • Gel composition, patch and application thereof
  • Gel composition, patch and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 is the optimal film-forming gel. The products (see Table 1) obtained by the formula of Example 1 are added one by one into the small chamber of the spot tester, and after the back is closed and applied for 24 hours, the results are observed 24 hours after the application , figure 1 It shows that the erythema caused by Example 1 is very uniform, erythema occurs in all 10 small chambers, and the erythema is evenly seen in the small chamber and the small chamber. The inventor conducted the same experiment with the products prepared in Examples 2-6, and compared with the comparative examples, they all had good repeatability and uniformity.

[0027] Table 1 Embodiment 1 formula detailed list

[0028]

[0029]

[0030] Preparation Process:

[0031] 1. Phase A is stirred and dissolved evenly;

[0032] 2. After the water of phase B and acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer (U20) are soaked and swelled completely, stir and disperse e...

Embodiment 2

[0035] Table 2 Embodiment 2 formula detailed list

[0036]

[0037] Preparation Process:

[0038] 1. Phase A is stirred and dissolved evenly;

[0039] 2. After the water of phase B and acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer (U20) are soaked and swelled completely, stir and disperse evenly, add 1,2-pentanediol and stir evenly, add 10% Adjust the pH to 5.5-6 with NaOH, add polyurethane-35 (C1004), stir evenly, add phase A, stir evenly;

[0040] 3. Add the phase C raw materials, stir well and then discharge.

Embodiment 3

[0042] Table 3 Embodiment 3 formula detailed list

[0043]

[0044] Preparation Process:

[0045] 1. Phase A is stirred and dissolved evenly;

[0046] 2. After the water of phase B and acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer (U20) are soaked and swelled completely, stir and disperse evenly, add 1,2-pentanediol and stir evenly, add 10% Adjust the pH to 5.5-6 with NaOH, add polyurethane-35 (C1004), stir evenly, add phase A, stir evenly;

[0047] 3. Add the phase C raw materials, stir well and then discharge.

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PUM

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Abstract

The invention discloses a gel composition, patch and application thereof. The gel composition of the present invention includes a film former, a thickener, a penetration enhancer and a solvent. The use of the gel composition in patch products can solve the problem of unstable results of antagonistic stimulus patches and reduce misjudgment of results caused by unstable stimulus modeling.

Description

technical field [0001] The invention specifically relates to a gel composition, patch and application thereof. Background technique [0002] The choice of substrate for product irritation or antagonistic stimulation test is very important. The erythema carried by a good substrate is relatively uniform and highly repeatable, and it plays a role in whether the addition of inhibitors can produce a stable dose-effect relationship and obtain accurate test results. decisive role. [0003] Patch test has low accuracy due to factors such as matrix and individual differences. In the prior art, due to unreasonable choice of matrix, uneven erythema and poor repeatability of concentration gradient, it is difficult to accurately judge the detection of irritation or antagonistic irritation. At present, the use of closed human body patch for SDS antagonistic stimulation test uses more water agents as substrates, and the erythema produced by water agents carrying SDS is not uniform, and th...

Claims

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Application Information

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IPC IPC(8): A61K49/00
CPCA61K49/0006
Inventor 董银卯刘宇红李静秦哲
Owner 三立慧评(北京)检测技术有限公司
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