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Test methods for the irritation of cosmetic raw materials and anti-irritation products for anti-irritants

A detection method and cosmetic technology, which can be applied to measurement devices, analysis materials, and material analysis by optical means, etc., can solve the problems of less research, and achieve the effects of accurate research results, improvement of unstable results, and reduction of misjudgment of results.

Active Publication Date: 2022-05-20
三立慧评(北京)检测技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, in order to improve the accuracy of the patch detection results, the uniformity, repeatability, and stability of the patch matrix to the erythema are studied to ensure the accuracy of the anti-irritation test results, and the patch test interpretation method is improved to obtain There are few studies on accurate and dose-effective test results

Method used

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  • Test methods for the irritation of cosmetic raw materials and anti-irritation products for anti-irritants
  • Test methods for the irritation of cosmetic raw materials and anti-irritation products for anti-irritants
  • Test methods for the irritation of cosmetic raw materials and anti-irritation products for anti-irritants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The product (see Table 1) obtained by the formula of Example 1 is added one by one in the small chamber of the spot tester, and after the back is closed and applied for 24 hours, the result is observed 24 hours after the connection. figure 1 Show, the erythema that embodiment 1 causes is very uniform, and erythema all occurs in 10 small chambers, and sees erythema evenly in small chamber and small chamber, inventor has carried out same patch test with the product prepared in embodiment 2-6, compared with The proportions have good repeatability and uniformity.

[0054] Example 1 erythema pictures and erythema value analysis results see Figure 5 , 6 .

[0055] Table 1 Embodiment 1 formula detailed list

[0056]

[0057]

[0058] Preparation Process:

[0059] 1. Phase A is stirred and dissolved evenly;

[0060] 2. After the water of phase B and acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer (U20) are soaked and swelled completely, stir and dis...

Embodiment 2

[0063] Table 2 Embodiment 2 formula detailed list

[0064]

[0065] Preparation Process:

[0066] 1. Phase A is stirred and dissolved evenly;

[0067] 2. After the water of phase B and acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer (U20) are soaked and swelled completely, stir and disperse evenly, add 1,2-pentanediol and stir evenly, add 10% Adjust the pH to 5.5-6 with NaOH, add polyurethane-35 (C1004), stir evenly, add phase A, stir evenly;

[0068] 3. Add the phase C raw materials, stir well and then discharge.

Embodiment 3

[0070] Table 3 Embodiment 3 formula list

[0071]

[0072] Preparation Process:

[0073] 1. Phase A is stirred and dissolved evenly;

[0074] 2. After the water of phase B and acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer (U20) are soaked and swelled completely, stir and disperse evenly, add 1,2-pentanediol and stir evenly, add 10% Adjust the pH to 5.5-6 with NaOH, add polyurethane-35 (C1004), stir evenly, add phase A, stir evenly;

[0075] 3. Add the phase C raw materials, stir well and then discharge.

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Abstract

The invention discloses a method for detecting the anti-irritation properties of an anti-irritation product, comprising step 1) obtaining an image of the skin or a skin mimic after patch treatment, wherein the patch is coated with the anti-irritation product and Gel composition of irritants; step 2) Measure erythema characteristic values ​​in images of said skin or skin mimic. The invention also discloses a detection method for the irritation of cosmetic raw materials, a gel composition and a patch. The detection method provided by the present invention not only has good repeatability, but also can score the results of antagonistic stimulation in a more detailed manner, while avoiding the influence of human subjectivity, so as to evaluate the antagonistic stimulation effect of antistimulant products more accurately and objectively.

Description

technical field [0001] The invention belongs to the field of cosmetics, and specifically relates to a method for detecting the irritation of cosmetic raw materials and an anti-irritation product for anti-irritation products. The invention also relates to a gel composition and a patch. Background technique [0002] The patch test is greatly affected by factors such as the patch substrate, individual differences, and interpretation methods. The choice of patch substrate for product irritation or antagonistic stimulation test is very important. The erythema carried by a good substrate is relatively uniform and has high repeatability, and can produce a stable dose-effect relationship and accurate test results after adding inhibitors. play a decisive role. [0003] Due to the unreasonable selection of the matrix, the uneven erythema and the poor repeatability of the concentration gradient make it difficult to accurately judge the irritation or antagonistic irritation detection. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/84
CPCG01N21/84
Inventor 董银卯李静刘宇红秦哲
Owner 三立慧评(北京)检测技术有限公司
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