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Coating and material to promote vascular intimal repairing, preparation method of material and medical product

A technology of vascular intima and coating, which is applied in the field of biomedical materials, can solve the problems of non-specific performance in promoting endothelial cell adhesion, and achieve the effect of promoting endothelial cell viscosity, promoting repair, and promoting adhesion

Inactive Publication Date: 2019-07-05
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a coating for promoting the repair of vascular intima, aiming at improving the problems that existing blood-contacting biomaterials do not have the ability to specifically promote the adhesion of endothelial cells

Method used

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  • Coating and material to promote vascular intimal repairing, preparation method of material and medical product
  • Coating and material to promote vascular intimal repairing, preparation method of material and medical product
  • Coating and material to promote vascular intimal repairing, preparation method of material and medical product

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] A method for preparing a material for promoting vascular intima repair, comprising:

[0029] A coating containing copper-based MOF and grafted with an amino-containing polypeptide is coated on the surface of the base material, and the amino-containing polypeptide is a polypeptide that specifically promotes endothelial cell adhesion; specifically, the amino-containing polypeptide includes a polypeptide containing REDV , at least one of a CAG-containing polypeptide and a SVVYGLR-containing polypeptide.

[0030] Specifically include:

[0031] S1. Initial modification: soak the base material in the initial modification solution to obtain a base material with a copper-based MOF-containing solution on the surface, clean and dry the base material with a copper-based MOF-containing solution on the surface, The primary modification material is obtained, and the primary modification solution is a Tris buffer solution in which dopamine and copper-based MOF are dissolved.

[0032...

Embodiment 1

[0048] A preparation method of a material for promoting vascular intima repair provided in this embodiment, comprising:

[0049] The trimesic acid was dissolved in absolute ethanol to obtain an absolute ethanol solution of trimesic acid with a final concentration of 0.04 g / ml. It is claimed that copper hydroxide is dissolved in deionized water under the condition of microwave-assisted dissolution to obtain a copper hydroxide solution with a final concentration of 0.05 g / ml. Mix 2.14 volumes of trimesic acid in absolute ethanol and 1 volume of copper hydroxide solution, and stir mechanically for 10 h. After the reaction is completed, the obtained product is suction-filtered, and then washed repeatedly with absolute ethanol and deionized water to obtain relatively pure copper trimesic acid; finally, the obtained product is air-dried for future use.

[0050] The base material is polished, cleaned and dried for later use.

[0051] Copper trimesate and dopamine were dissolved in ...

Embodiment 2

[0056] A preparation method of a material for promoting vascular intima repair provided in this embodiment, comprising:

[0057] The trimesic acid was dissolved in absolute ethanol to obtain an absolute ethanol solution of trimesic acid with a final concentration of 0.4 g / ml. Said that copper hydroxide was dissolved in deionized water under the condition of microwave-assisted dissolution to obtain a copper hydroxide solution with a final concentration of 0.5 g / ml. Mix 2.14 volumes of trimesic acid in absolute ethanol and 1 volume of copper hydroxide solution, and stir mechanically for 20 h. After the reaction is completed, the obtained product is suction-filtered, and then washed repeatedly with absolute ethanol and deionized water to obtain relatively pure copper trimesic acid; finally, the obtained product is air-dried for future use.

[0058] The base material is polished, cleaned and dried for later use.

[0059] Copper trimesate and dopamine were dissolved in Tris buffe...

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Abstract

The invention relates to the field of biomedical materials and provides coating to promote vascular intimal repairing. An amino-containing polypeptide and a copper-based MOF (metal-organic framework)are grafted to the surface of the coating; the amino-containing polypeptide is capable of specifically promoting adhesion of endothelial cells. A material to promote vascular intimal repairing comprises a substrate material; the coating to promote vascular intimal repairing is attached to the surface of the substrate material. A preparation method of the material to promote vascular intimal repairing comprises coating the surface of the substrate material with the copper-based MOF and the coating which the amino-containing polypeptide is grafted to; the amino-containing polypeptide can specifically promote adhesion of the endothelial cells; a medical product is made with the above material to promote vascular intimal repairing. All the coating, the material and the medical product providedherein can specifically promote adhesion and growth of endothelial cells, and reduce damage to the endothelial cells in a peroxidation micro environment.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a coating, a material, a preparation method of the material and a medical product for promoting vascular intima repair. Background technique [0002] At present, forming a complete endothelialized layer on the surface or promoting the in situ repair of the intima to obtain excellent blood compatibility and tissue compatibility is the research goal of biomaterials in contact with blood, and has become a research hotspot in this field. The existing technology promotes the adhesion, proliferation and migration of endothelial cells on the material surface by immobilizing or grafting vascular growth factors, target genes and polypeptide sequences on the material surface. In the study, peptides with specific endothelial cell adhesion promotion, such as REDV, CAG, etc., were immobilized on the surface of the material. The grafting of peptides promoted the adhesion of endothelial cell...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/08A61L31/14A61L31/16
CPCA61L31/08A61L31/10A61L31/14A61L31/16A61L2300/252A61L2300/412A61L2400/18A61L2420/02A61L2420/06C08L89/00
Inventor 翁亚军谢银红范永鸿曾峥赵倩张雨刘峻峰李伟杰
Owner SOUTHWEST JIAOTONG UNIV
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