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A method for extracting ellagic acid and chebulic acid in chebula and its composition

A composition, the technology of chebulic acid, which is applied in the field of extraction method of ellagic acid and chebulinic acid in chebula and its composition, can solve the problems of complex purified components and low purity, and achieve the purpose of extraction with strong pertinence and high purity. High, simple effects of variety

Active Publication Date: 2022-05-10
内蒙古阿尔善药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In order to solve the problems of complex purified components and low purity in the prior art, the present invention provides a method for extracting ellagic acid and chebulic acid in chebula, comprising the following steps:

Method used

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  • A method for extracting ellagic acid and chebulic acid in chebula and its composition
  • A method for extracting ellagic acid and chebulic acid in chebula and its composition
  • A method for extracting ellagic acid and chebulic acid in chebula and its composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Extraction method of ellagic acid and chebulic acid:

[0072] (1) pretreatment: 200 mesh sieves are pulverized by Myrobalan;

[0073] (2) Extraction 1: reflux extraction of pulverized chebula, the solvent used for reflux extraction is methanol-ethanol-water solution, wherein methanol:ethanol:water=5:5:1, solvent: chebula=8:1, and then pass Microporous membrane to obtain solid A and extract A; reflux extraction conditions are: reflux temperature is 45°C; reflux time is 1h

[0074] (3) Extraction 2: The solid A is subjected to reflux extraction again, and the solvent used for reflux extraction is acetic acid-water solution, wherein, acetic acid: water = 2: 1, solvent: chebula = 5: 1, and then pass through a microporous membrane to obtain Solid B and extract B; reflux extraction conditions are: reflux temperature is 80°C; reflux time is 1h.

[0075] (4) Separation: Mix extract A and extract B, concentrate, pass through HPD-100 macroporous adsorption resin, mass fraction ...

Embodiment 2

[0080] Extraction method of ellagic acid and chebulic acid:

[0081] (1) pretreatment: 300 mesh sieves are pulverized by Myrobalan;

[0082] (2) Extraction 1: reflux extraction of the pulverized chebula, the solvent used for reflux extraction is methanol-ethanol-water solution, wherein methanol:ethanol:water=5:10:1, solvent: chebula=12:1, and then pass Microporous membrane to obtain solid A and extract A; reflux extraction conditions are: reflux temperature is 65°C; reflux time is 3h

[0083] (3) Extraction 2: The solid A is subjected to reflux extraction again, and the solvent used for reflux extraction is acetic acid-water solution, wherein, acetic acid: water = 5: 1, solvent: chebula = 10: 1, and then pass through a microporous membrane to obtain Solid B and extract B; reflux extraction conditions are: reflux temperature is 65°C; reflux time is 3h.

[0084] (4) Separation: Mix extract A and extract B, concentrate, pass through SD-300 macroporous adsorption resin, mass fra...

Embodiment 3

[0089] Extraction method of ellagic acid and chebulic acid:

[0090] (1) pretreatment: the chebula is pulverized and crossed 250 mesh sieves;

[0091] (2) Extraction 1: Reflux extraction of pulverized chebula, the solvent used for reflux extraction is methanol-ethanol-water solution, wherein methanol:ethanol:water=5:8:1, solvent: chebula=10:1, and then pass Microporous membrane to obtain solid A and extract A; reflux extraction conditions are: reflux temperature is 50°C; reflux time is 2h

[0092] (3) Extraction 2: The solid A is subjected to reflux extraction again, and the solvent used for reflux extraction is acetic acid-water solution, wherein, acetic acid: water = 3: 1, solvent: chebula = 8: 1, and then pass through a microporous membrane to obtain Solid B and extract B; reflux extraction conditions are: reflux temperature is 70°C; reflux time is 2h.

[0093] (4) Separation: Mix extract A and extract B, concentrate, pass through D-101 macroporous adsorption resin, and e...

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Abstract

The invention relates to the field of traditional Chinese medicine extracts, in particular to a method for extracting ellagic acid and chebulic acid from chebula chebula and a composition thereof. The method includes the following steps: pretreatment, pulverizing and sieving the chebula; refluxing and extracting the pulverized chebula, and then passing through a microporous membrane to obtain solid A and extract A; refluxing and extracting the solid A, and then passing through a micropore Filter the membrane to obtain solid B and extract B; mix extract A and extract B, concentrate, pass through a macroporous adsorption resin, elute with a solvent, crystallize and dry to obtain ellagic acid and chebulic acid in myrobalan. The extraction method of the invention can specifically extract the ellagic acid and the chebulic acid in the chebula, and the content and purity are relatively high. The invention also provides a product which has positive effects on treating hypertension and hyperlipidemia, and also has the effect of reducing inflammation and improving eyesight.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine extracts, in particular to a method for extracting ellagic acid and chebulic acid from chebula chebula and a composition thereof. Background technique [0002] With the rapid development of the economy, people's dietary structure and habits have undergone relatively large changes, and many people also cause excessive energy intake while gluttonous meals, so the so-called "rich man's disease" represented by high blood pressure and high blood fat "One after another. Hypertension and hyperlipidemia are the source of many diseases. With people's high-fat and high-salt diet and unreasonable eating habits, the human body's metabolism is disordered. High fat can lead to elevated blood lipids, and hyperlipidemia is a risk factor for stroke, coronary heart disease, myocardial infarction, and sudden death. In addition, hyperlipidemia is also an important risk factor for hyperlipidemia, impaired...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K36/744A61P9/12A61P3/06A61P27/02A61P29/00A23F3/34
CPCA61K36/286A61K36/185A61K36/744A61K36/484A61P9/12A61P3/06A61P27/02A61P29/00A23F3/34A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 白吉日木吐李金柱张海玉赖苏雅拉吐
Owner 内蒙古阿尔善药业有限公司
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