Defatted wheat germ powder extract and new use thereof

A technology of wheat germ powder and extract, applied in food extraction, application, food science, etc., can solve the problems of hindering ferrous iron from releasing oxygen, being unable to transport oxygen, hindering oxygen transport and utilization, etc.

Inactive Publication Date: 2019-07-02
HENAN COOP MEDICAL SCI & TECH INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ferric iron not only cannot transport oxygen, but also hinders the release of oxygen by the ferrous iron of the same hemoglobin, shifts the dissociation curve of oxyhemoglobin to the left, and further hinders the transport and utilization of oxygen
In addition, at present, there are almost no reports about other effective drugs for the prevention and treatment of nitrite poisoning at home and abroad, so it is feasible to use wheat germ globulin oral liquid as a drug for the prevention and treatment of nitrite poisoning

Method used

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  • Defatted wheat germ powder extract and new use thereof
  • Defatted wheat germ powder extract and new use thereof
  • Defatted wheat germ powder extract and new use thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0022] A kind of defatted wheat germ powder extract and its new application, described a kind of defatted wheat germ powder extract is wheat germ globulin oral liquid, it is characterized in that defatted wheat germ powder is used as main raw material; Wheat germ conglutinin is extracted, which is also characterized in that its preparation method comprises the steps of defatting wheat germ flour:

[0023] Step 1: crushing the defatted wheat germ and passing through a 130-mesh sieve;

[0024] Step 2: Add 10 times sterilized pure water to the crushed defatted wheat germ, put it into a constant temperature oscillator for extraction (temperature 30°C, extraction time 60 min);

[0025] Step 3: After leaching, centrifuge (5000 r / min, 20 min) to discard the supernatant, take out the sediment and inoculate it with 0.01% Lactobacillus plantarum, mix it evenly and spread it on a stainless steel shallow plate, the thickness 0.5 cm. The fermentation temperature was 37°C, and the aerobic...

Embodiment 2

[0030] A kind of defatted wheat germ powder extract and its new application, described a kind of defatted wheat germ powder extract is wheat germ globulin oral liquid, it is characterized in that defatted wheat germ powder is used as main raw material; Wheat germ conglutinin is extracted, which is also characterized in that the preparation method of its extract from defatted wheat germ flour comprises the following steps:

[0031] Step 1: crushing the defatted wheat germ and passing through a 130-mesh sieve;

[0032] Step 2: Add 9 times sterilized pure water to the crushed defatted wheat germ, put it into a constant temperature oscillator for extraction (temperature 30°C, extraction time 50 min);

[0033] Step 3: After leaching, centrifuge (4500 r / min, 15 min) to discard the supernatant, take out the sediment and inoculate it with 0.01% Lactobacillus plantarum, mix it evenly and spread it on a stainless steel shallow plate, the thickness 0.7 cm. The fermentation temperature ...

Embodiment 3

[0038] Experiment 1: Acute oral toxicity experiment

[0039] The product of wheat germ globulin oral liquid was tested for acute oral toxicity by the technology center of Xi'an Guolian Quality Inspection Technology Co., Ltd. in accordance with GB15193.3-2014 "National Food Safety Standard Acute Oral Toxicity Test". The test conclusion: according to GB15193.3 -2014 Acute Oral Toxicity Test Grading Standards, under the test conditions of this institution, the acute oral LD50 of wheat germ globulin oral liquid on Kunming mice > 10000 mg / kg body weight, which is actually non-toxic, see the test report figure 1 .

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Abstract

The invention discloses a defatted wheat germ powder extract and a new use thereof. The extract comprises a main component of wheat germ globulin, defatted wheat germ powder is extracted by a sodium chloride solution with the mass concentration of 2%-4%, and a wheat germ globulin oral liquid is prepared. The invention also provides the use of the defatted wheat germ powder extract (namely the wheat germ globulin oral liquid) in drugs for preventing or treating acute nitrite poisoning. The wheat germ globulin oral liquid has remarkable detoxification effect, can significantly shorten the phenomenon of mice after nitrite poisoning, and can prevent and treat nitrite poisoning. The wheat germ globulin oral liquid is verified to have no toxic or side effects by toxicological experiments, is verified to have good preventive and therapeutic effects on mice with acute nitrite poisoning by pharmacological experiments, and has broad market prospects and important economic and social benefits.

Description

technical field [0001] The invention relates to the technical field of formula food for special medical purposes (FSMP), in particular to a defatted wheat germ powder extract and its new application. Background technique [0002] In recent years, there have been endless reports of food poisoning, mainly in the catering industry, campuses, and especially kindergartens. The culprit is sodium nitrite. Sodium nitrite (NaNO 2 ) is an important industrial raw material, and it is also a food additive and animal feed additive that are often used in daily life. Generally, 0.3~0.5g of nitrite ingested by the human body can cause poisoning. Nitrite poisoning (alias: enterogenic cyanosis, black mouth disease, English: Nitrite poisoning) refers to poisoning caused by eating cured meat products with high nitrate or nitrite content, pickles and spoiled vegetables, Or it is caused by eating industrial sodium nitrite as table salt by mistake. Nitrite can change the hemoglobin in the organ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/185A61K38/16A61P39/02
CPCA23L33/185A61K38/168A61P39/02A23V2002/00A23V2400/169A23V2200/30A23V2250/5486A23V2300/14
Inventor 黄继红吕行张相生侯银臣冯军伟廖爱美赵祎
Owner HENAN COOP MEDICAL SCI & TECH INST CO LTD
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