Application of lncrna11496 in the diagnosis and treatment of toxoplasmosis

Abstract

The invention provides the application of lncRNA11496 in the diagnosis and treatment of toxoplasmosis, which belongs to the technical field of biomedicine and molecular biology. The study found that NONMMUG011496 (lncRNA11496) was significantly down-regulated in the brain tissue of Toxoplasma gondii-infected mice infected by microarray; at the same time, the expression of lncRNA11496 in the brain tissue of Toxoplasma gondii chronically infected mice affected the proliferation, differentiation and apoptosis of nerve cells, and Toxoplasma infection is closely related. lncRNA11496 is a non-coding RNA discovered for the first time in brain tissue chronically infected by Toxoplasma gondii. Therefore, lncRNA11496 can be used as an important biological target, which provides a basis for the diagnosis of toxoplasmosis encephalopathy and the development of anti-toxoplasma drugs based on lncRNA11496, which has good practical application value.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and molecular biology, and specifically relates to the application of lncRNA11496 in the diagnosis and treatment of toxoplasmosis. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Toxoplasma gondii is an obligate intracellular parasite. The first human case was reported in 1908. It was discovered at the same time as animal toxoplasmosis. About 500 to 1 billion people in the world are infected with toxoplasmosis. Humans have been fighting against this disease for more than a century, but the disease is still around the world. raging. In my country, about 80,000 to 90,000 newborns are born e...

AI Technical Summary

Problems solved by technology

The use of traditional etiological inspection methods such as microscopic examination and parasite isolation method has the disadvantages of time-consuming and laborious, and the specificity and sensitivity are not high

Immunological diagnosis method, that is, to detect Toxoplasma gondii antibody, but patients with toxoplasmosis are often accompanied by low immune function, and the antibody level often decreases, making it difficult to make a correct diagnosis

The diagnostic method of molecular biology has the advantages of simplicity, quickness, good sensitivity, and high specificity. The inventors found that currently used diagnostic gene targets include B1, ITS-1, P30 genes, etc., but these diagnostic genes have poor specificity, low copy number defect

In particular, there is no specific target for the diagnosis and treatment of brain toxoplasmosis

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