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Application of geraniin in preparation of drugs to prevent or treat atherosclerosis

A technology for atherosclerosis and geranium can be used in the field of medicine, which can solve the problems of residual patients and other problems, and achieve the effects of less toxic and side effects, a wide range of sources and controllable quality.

Inactive Publication Date: 2019-06-21
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although statins can lower cholesterol levels and have a certain degree of anti-inflammatory activity, patients still have residual risks after statins and other conventional anti-AS drugs

Method used

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  • Application of geraniin in preparation of drugs to prevent or treat atherosclerosis
  • Application of geraniin in preparation of drugs to prevent or treat atherosclerosis
  • Application of geraniin in preparation of drugs to prevent or treat atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Get 5 grams of geraniin, add conventional adjuvants for preparing medicines, such as adding 3 g of starch, 2 g of microcrystalline cellulose, and 0.1 g of magnesium stearate, mix well, and adopt methods known in the art to make tablets and capsules or granules.

Embodiment 2

[0027] Take 2 grams of geraniin, mix it evenly with good water-soluble auxiliary materials, put it into 10ml aqueous solution, add conventional auxiliary materials to improve taste and enhance stability, and use methods known in the art to make oral liquid.

Embodiment 3

[0028] Example 3 Pharmacodynamic experiment of geraniin on atherosclerosis

[0029] 1. Geraniin reduces lipid components in atherosclerotic plaques in ApoE- / - mice

[0030] In order to confirm the anti-AS effect of geraniin, we adopted ApoE- / - mice with high-fat feeding to establish AS plaque models, and divided them randomly into choline diet group and choline diet+geraniin group (each Group n=8), wherein the choline diet group was given choline diet and the same amount of normal saline as geranin; d, After 12 weeks of continuous administration, the aortic root of the mouse was taken to make frozen pathological sections and stained with Oil Red O. The content of lipid components in the plaque was reflected by the area of ​​Oil Red O positive area.

[0031] Experimental results such as figure 1 as shown, figure 1 The results confirmed that geraniin can significantly reduce the lipid composition in the plaque.

[0032] 2. Geraniin reduces macrophages in atherosclerotic pla...

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Abstract

The invention discloses application of geraniin in the preparation of drugs to prevent or treat atherosclerosis. Experiments verify that geraniin can diminish atherosclerotic plaque area and prevent or treat atherosclerosis by reducing lipids in atherosclerotic plaques and reducing macrophages in the atherosclerotic plaques. The provision of the application helps provide a drug with clear effect and composition and controllable quality for the prevention or treatment of atherosclerosis; geraniin is derived from natural plants; drugs made with geraniin as a main effective component are widely resourceful, has low toxic and side effects and are suitable for atherosclerotic patients to take often.

Description

technical field [0001] The invention relates to the application of geraniin in the preparation of drugs for preventing or treating atherosclerosis. The invention belongs to the technical field of medicine. Background technique [0002] The mortality rate of cardiovascular diseases in my country has been ranked first for many years, higher than that of tumors and other diseases, and the prevalence rate is on the rise, which brings a heavy burden to the national economy. Atherosclerosis (AS) is the pathological basis of cardiovascular diseases. It is particularly important to clarify the pathogenesis of AS and find effective therapeutic targets. [0003] The pathogenesis of AS is very complicated. In the early stage, endothelial injury triggers an inflammatory response, recruits monocytes to migrate below the endothelium, differentiates into macrophages under the action of various cytokines, and phagocytizes lipids (especially oxidized low-density lipoprotein, oxLDL) form fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P9/10
Inventor 于波刘新新田进伟侯静波尹力王学懂李吉
Owner HARBIN MEDICAL UNIVERSITY
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