High-sensitivity online device for detecting HCN in expiratory air, and application thereof

Abstract

The invention provides a high-sensitivity online device for detecting HCN in expiratory air, and an application thereof. The high-sensitivity online analysis system comprises an expiratory air sampling device, an expiratory air dehumidifying device, an air supply device and an HCN high-sensitivity detecting device. The application of the high-sensitivity online analysis system is to use the abovehigh-sensitivity online analysis system to directly convey human body expiratory air with a certain flow rate into the HCN high-sensitivity detecting device for analysis after the dehumidifying treatment of the dehumidifying device. HCN gases with different concentrations can be obtained by changing the flow rate of the human body expiratory air and the pumping speed of a pump, so as to obtain HCNfeature ion signal responses of different intensities. The human body expiratory air directly enters the HCN high-sensitivity detecting device without offline pre-enrichment, chemical derivation or other pretreatment steps, so that the operation is simple, the analysis is fast and accurate, the detection sensitivity is high, and the HCN of the sub-ppbv order can be detected.

Description

technical field [0001] The present invention relates to a high-sensitivity online detection device and application of HCN in exhaled air. Specifically, the high-sensitivity online analysis device is used to directly sample and analyze human exhaled air at a specific flow rate after dehumidification, so as to achieve high-sensitivity online analysis. Purpose of HCN in exhaled breath. Background technique [0002] As a genetic disease, cystic fibrosis is a chronic inflammatory lung infection that recurs periodically, causing progressive respiratory failure and, in severe cases, death. Currently, in the UK alone, more than 9,000 people suffer from the disease each year, with a particularly high incidence among children. Therefore, finding biomarkers of cystic fibrosis is crucial for the early diagnosis and treatment of the disease. The researchers found that one of the most common and important pathogens causing cystic fibrosis is called Pseudomonas aeruginosa, and the Pseudo...

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Problems solved by technology

However, the proton affinity of HCN is the same as that of H 2 O is very close (3 o + The proton transfer reaction between is reversible, limiting the H 2 CN + Yield of

In addition, due to the long reaction zone of SIFT-MS, when the sample gas humidity is high, it is easy to generate cluster ions H of multiple water molecules. 2 CN(H 2 O) n + , which further limits the improvement of HCN detection sensitivity

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