Marker for locally advanced esophageal squamous cell carcinoma prognosis and application of marker

Abstract

The invention relates to the field of bioengineering and tumor markers, in particular to a marker for locally advanced esophageal squamous cell carcinoma prognosis and an application of the marker. The marker is a combined marker consisting of one or more of miR-135b-5p, miR-139-5p, miR-29c-5p and miR-338-3p, and locally advanced esophageal squamous cell carcinoma prognosis is predicted by detecting expression levels of the four miRNA in tumor tissue and performing calculation according to a formula (0.4690*miR-135b-5p expression level)+(0.3839*miR-139-5p expression level)+(0.1733*miR-29c-5p expression level)+(0.3368*miR-338-3p expression level). The combined marker has the advantages of good stability and high sensitivity and specificity and can more accurately and more valuably evaluateprognosis of patients than traditional clinical pathological factors such as TNM (tumor-node-metastasis) staging and the like. On one hand, the molecular marker related to esophageal squamous cell carcinoma prognosis is provided, on the other hand, an esophageal squamous cell carcinoma prognosis prediction model is established, so that individual treatment of esophageal squamous cell carcinoma isrealized, the comprehensive treatment level of the esophageal squamous cell carcinoma is improved, the life quality of esophageal squamous cell carcinoma patients is improved, and the lifetime of theesophageal squamous cell carcinoma patients is prolonged.

Description

technical field [0001] The invention relates to the fields of bioengineering and tumor markers, in particular to a marker used for prognosis judgment of locally advanced esophageal squamous cell carcinoma and its application. Background technique [0002] Esophageal cancer is one of the most malignant tumors in the digestive tract. Esophageal cancer can be divided into esophageal adenocarcinoma and esophageal squamous cell carcinoma. In my country, 95% of esophageal cancer is esophageal squamous cell carcinoma. The third and fourth place, accounting for more than half of the global incidence and mortality of esophageal cancer, is a disease that seriously endangers the health of the Chinese people. Surgery is still an important treatment method for locally advanced esophageal squamous cell carcinoma in my country. However, due to the wide existence of tumor heterogeneity, even patients with different esophageal squamous cell carcinomas of the same clinical stage, after receivi...

AI Technical Summary

Problems solved by technology

However, based on the previous research on miRNA molecular markers related to the prognosis of esophageal squamous cell carcinoma, there are problems such as the small number of miRNAs screened, the small number of cases, and the lack of independent verification cohorts in some studies.

Some studies only use the detection of a single miRNA molecule as an indicator of prognosis, and the effect is not as good as combining multiple miRNA molecules. In addition, there is a lack of objective evaluation of the prognostic value of miRNA markers

Images