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Method for mining radiotherapy specific genes of colorectal cancer by using weight gene co-expression network

A colorectal cancer, co-expression technology, applied in genomics, instrumentation, proteomics, etc., to reduce mortality, improve survival prognosis, and solve clinical problems

Active Publication Date: 2019-06-11
辽宁省肿瘤医院
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Problems solved by technology

Many genes and their protein products related to colorectal cancer have been explored, but few studies have used the weighted gene co-expression network to explore the differential genes before and after cancer radiotherapy

Method used

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  • Method for mining radiotherapy specific genes of colorectal cancer by using weight gene co-expression network
  • Method for mining radiotherapy specific genes of colorectal cancer by using weight gene co-expression network
  • Method for mining radiotherapy specific genes of colorectal cancer by using weight gene co-expression network

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Embodiment Construction

[0050] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the teachings of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0051] Example A method for mining colorectal cancer radiotherapy-specific response genes using a weighted gene co-expression network.

[0052] 1. Data preprocessing.

[0053] The microarray data of rectal cancer extracted from the GSE15781 data set has a total of 42 samples, including 9 samples of cancer radiotherapy, 13 samples of cancer without radiotherapy, 10 samples of normal non-radiation therapy, and 10 samples of norm...

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Abstract

The invention relates to a weight gene co-expression network, and specifically relates to a method for mining radiotherapy specific genes of colorectal cancer by using a weight gene co-expression network. The method for mining radiotherapy specific genes of colorectal cancer by using a weight gene co-expression network provides a new way to mine the specific response genes of colorectal cancer byusing the weight gene co-expression network, and provides a new basis for predicting the survival prognosis of patients with colorectal cancer. The radiotherapy of the target gene discovered by the method of the present invention can improve the survival prognosis of patients with colorectal cancer to some extent, can reduce the mortality of the patients with colorectal cancer, can solve the actual clinical problems, and can provide a better choice for the majority of patients.

Description

technical field [0001] The invention relates to a weighted gene co-expression network, in particular to a method for mining colorectal cancer radiotherapy-specific genes by using the weighted gene co-expression network. Background technique [0002] Colorectal cancer is a malignant tumor with high incidence in China and the world, accounting for about 10% of all cases. It has high mortality, easy recurrence, and poor prognosis. genetic disease caused. Global Burden of Disease (GBD) data shows that in 2016, the number of people suffering from colorectal cancer in the world reached 6.32 million, of which the number of patients in China was as high as 1.47 million. In 2016, the number of deaths from colorectal cancer patients worldwide was 830,000, of which more than 160,000 died in China, accounting for 1.73% of the total deaths. Statistics show that from 1990 to 2016, the prevalence and mortality of colorectal cancer continued to increase globally, and the prevalence and mo...

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Application Information

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IPC IPC(8): G16B20/00G16B40/00
Inventor 王哲刘星吾
Owner 辽宁省肿瘤医院
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