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A microrna molecular marker and its application for screening the saliva of acute altitude sickness susceptible persons

A technology of molecular markers and altitude sickness, applied in the field of molecular biotechnology and its application, to achieve the effect of reducing pain and risk, strong reliability, and good screening efficiency

Active Publication Date: 2022-04-01
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few reports on the correlation between circulating microRNA and AMS susceptibility.

Method used

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  • A microrna molecular marker and its application for screening the saliva of acute altitude sickness susceptible persons
  • A microrna molecular marker and its application for screening the saliva of acute altitude sickness susceptible persons
  • A microrna molecular marker and its application for screening the saliva of acute altitude sickness susceptible persons

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Correlation between expression of saliva specimens of microRNA and the risk of AMS onset

[0045] I. Collection of materials and specimens

[0046] AMS susceptible sputum specimens collected from AMS patients in the emergency platen into the plateau to enter the plateau, and 75 cases. The saliva specimens of the normal population collected the normal healthy population in the emergency grain population into the plateau, and 49 cases. The diagnosis of AMS is confirmed by the International General Diagnostic Standard - Lake Louis. All people did not take any preventive drugs before taking differentials. Each sample collected 10 ml of saliva with a sterile free 50 ml centrifuge tube. The patient's clinical case features are shown in Table 1. This study has approved by the Army Military Medical University (Third Military Medical University) Medical Ethics Committee, all specimen acquisition acquires the patient's informed consent.

[0047] Table 1 Clinical data of sal...

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PUM

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Abstract

The invention relates to a microRNA marker for screening the saliva of persons susceptible to acute altitude sickness, and the application of the microRNA in the preparation of reagents or kits for screening persons susceptible to acute altitude sickness. It also provides a kit for detecting hsa-miR-134-3p and hsa-miR-15b-5p molecules in the plain saliva of the tested human by real-time fluorescent quantitative PCR method, and predicts the acute plateau through its expression level Response to morbidity risk. Using microRNA in saliva samples as a molecular marker has the characteristics of strong specificity, high sensitivity, non-invasiveness, and convenience, and is suitable for large-scale screening of people susceptible to acute altitude sickness in the plains.

Description

Technical field [0001] The present invention belongs to molecular biotechnology and its application, and the present invention is directed to a microRNA molecular marker for screening acute plateau reactive spit, more involved in its application and kits. The risk of acute plateau reactivity is screened by HSA-MIR-15B-5P expression levels in saliva, thus used to assess the volatility of the human body on acute plateau reactions, and reduce the risk of acute plateau. Background technique [0002] Acute Mountain Sickness (AMS), is a plain person who has happened for a long time in low altitude. It produced 1-3 days after the rapid enters the plateau without adapting to the new environment, including headache, dizziness, fatigue, insomnia A series of symptoms such as emotional disappointment, gastrointestinal swelling, diarrhea and vomiting, which are typical symptoms of AMS. Geography is above 500m, the terrain is relatively flat, or has a wide range of undulating vast areas, and t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12N15/113
Inventor 黄河陈建高钰琪孙滨达鄂国基黄缄张二龙徐刚何姝柯贤峰董华平
Owner ARMY MEDICAL UNIV
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