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Method for preparing acicular acetaminophen crystal by time domain shaping femtosecond laser

A paracetamol and femtosecond laser technology, applied in the separation/purification of carboxylic acid amide, chemical/physical/physicochemical process of energy application, organic chemistry, etc., can solve the problem of long process time, poor controllability and complicated process and other problems, to achieve the effect of easy realization, low cost and pure components

Inactive Publication Date: 2019-06-11
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, some of these methods require template preparation, and the process is complicated, such as template method and multi-component crystallization method; some preparation processes are less controllable, such as metal-assisted and microwave accelerated evaporation crystallization methods and ultrasonic irradiation methods etc.; some need to maintain low temperature, the process takes a long time, such as rapid cooling method, etc.
These disadvantages greatly limit the commercial application of acicular acetaminophen crystals

Method used

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  • Method for preparing acicular acetaminophen crystal by time domain shaping femtosecond laser
  • Method for preparing acicular acetaminophen crystal by time domain shaping femtosecond laser
  • Method for preparing acicular acetaminophen crystal by time domain shaping femtosecond laser

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Embodiment 1

[0037] A method for preparing needle-shaped acetaminophen crystals by time-domain shaping femtosecond laser, irradiating the femtosecond laser into a supersaturated aqueous solution of acetaminophen, so that the supersaturated aqueous solution of acetaminophen is ionized to generate cavitation Bubbles, and with the collapse of the bubbles, acicular acetaminophen crystals are produced; that is, it is possible to change the block acetaminophen crystal structure into acicular acetaminophen crystal structure.

[0038] A device for implementing the above method, such as figure 1 As shown, it includes: a femtosecond laser 1, a first mirror 2, a half-transparent mirror 3, a second mirror 4, a third mirror 5, a fourth mirror 6, a fifth mirror 7, and a half-wave plate 8. Glan prism 9, first dichroic mirror 10, second dichroic mirror 11, CCD12, LED lamp 13, focusing objective lens 14, petri dish and acetaminophen solution 15, three-dimensional translation stage 16 and computer 17 ;

...

Embodiment 2

[0042] A method for preparing needle-shaped acetaminophen crystals by time-domain shaping femtosecond laser, irradiating the femtosecond laser into a supersaturated aqueous solution of acetaminophen, so that the supersaturated aqueous solution of acetaminophen is ionized to generate cavitation Bubbles, and with the collapse of the bubbles, acicular acetaminophen crystals are produced; that is, it is possible to change the block acetaminophen crystal structure into acicular acetaminophen crystal structure.

[0043] A device for implementing the above method, such as figure 1 As shown, it includes: a femtosecond laser 1, a first mirror 2, a half-transparent mirror 3, a second mirror 4, a third mirror 5, a fourth mirror 6, a fifth mirror 7, and a half-wave plate 8. Glan prism 9, first dichroic mirror 10, second dichroic mirror 11, CCD12, LED lamp 13, focusing objective lens 14, petri dish and acetaminophen solution 15, three-dimensional translation stage 16 and computer 17 ;

...

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Abstract

The invention relates to a method for preparing acicular acetaminophen crystal by a time domain shaped femtosecond laser, and belongs to the field of preparation of pharmaceutical crystal materials. The method comprises the following steps: (1) preparing a supersaturated solution of acetaminophen by using a heating device; (2) using a femtosecond laser irradiation method to enable the acetaminophen supersaturated solution to be ionized to generate cavitation bubbles and generate acicular acetaminophen crystal as the bubbles rupture; and (3) drying filtered acicular acetaminophen crystal by using a heating device. The method for preparing the acicular paracetamol crystal provided by the invention is carried out under normal temperature and normal pressure without any addition in the production, the manufacturing time is short, the ratio of the acetaminophen crystal is high, and the size is controllable.

Description

technical field [0001] The invention relates to a method for preparing needle-shaped acetaminophen crystals with a time-domain shaping femtosecond laser, and belongs to the field of preparation of pharmaceutical crystal materials. Background technique [0002] Crystallization is a widely used technique in solid-liquid separation methods, especially in the pharmaceutical and fine chemical industries for purification and obtaining granular products. It can determine many properties of the product, such as polymorphism, average size and purity, which directly affect biodissolution, absorption rate, activity and tableting properties. These in turn affect bioavailability. In the pharmaceutical industry, polymorphism is very important because different polymorphs of the same active biological ingredient (API) exhibit different filtration, tableting, dissolution and bioavailability. For example, for acetaminophen (paracetamol), one of the most commonly used antipyretic and analge...

Claims

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Application Information

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IPC IPC(8): C07C231/24C07C233/25B01J19/12
Inventor 姜澜王素梅王树博
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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