A nerve repair membrane and its preparation method and application

Abstract

The present invention relates to a nerve repair film and its preparation method and application, the nerve repair film comprises a lactide-caprolactone copolymer fiber film and coated on the lactide-caprolactone copolymer fiber film polypyrrole coating. The method comprises the following steps: (1) dissolving the lactide-caprolactone copolymer in a solvent to obtain an electrospinning stock solution; (2) performing an electrospinning operation on the electrospinning stock solution to obtain a lactide-caprolactone Caprolactone copolymer fiber membrane; (3) coating polypyrrole on the lactide-caprolactone copolymer fiber membrane to obtain the nerve repair membrane. The nerve repairing film has an excellent repairing effect on damaged nerves, and has strong processability and a suitable degradation rate.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a nerve repair membrane and its preparation method and application. Background technique [0002] Peripheral nerve injury is a common disabling condition in humans, often resulting in loss of mobility and sensory impairment. Today's clinical treatment has applied various methods to the treatment to restore the loss of function. End-to-end splices can be used for short nerve injuries, whereas for distant nerve deficits a nerve graft is needed to bridge the transected nerve. Nerve autografting is currently the clinical standard for treating peripheral nerve injuries with a gap of 5-10 mm, however this approach requires removal of a segment of the nerve from a secondary site in the body, which causes additional surgical pain, as well as sensory function at the donor site lost. Furthermore, disadvantages such as limited donor resources, insufficient donor ...

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Problems solved by technology

The obtained nano-polypyrrole chitin nerve guide has good electrical conductivity and controllable degradation, but its flexibility and hydrophilicity are poor, it is difficult to process later, and the nerve repair effect is not good

[0005] CN108503768A discloses a degradable polyurethane socket for nerve repair, the nerve repair socket is better combined with the slow-release layer, not only has good elasticity and high strength, but also the nerve growth factor or brain-derived nerve in the slow-release layer Growth factors can be used for suturing small gaps in nerves, improve the repair of nerve defects, and provide long-term stimulating factors and nutrients for nerve regeneration; in addition, using biodegradable materials with good biocompatibility, after implantation It can avoid or eliminate side effects such as inflammation, meet the requirements of biomedicine, and can be absorbed or excreted by the body without secondary surgery to remove it. However, the electrical conductivity of the nerve repair sleeve is poor, and it is not easy to repair the nerve.

[0006] CN109331225A discloses a degradable composite nerve guide, which adopts silk fibroin, collagen and hyaluronic acid with good biocompatibility as the raw materials of the nerve guide to enhance its degradability in the body and facilitate the absorption of the body; Polylactic acid-glycolic acid is added to the raw material to improve the mechanical properties of the nerve guide; heparin is covalently bonded to the material matrix to achieve a sustained release effect, and heparin promotes axon growth and is conducive to improving the quality of nerve regeneration; The zero-degree chemical cross-linking agent EDC / NHS is used to improve the stability of the drug so that it can be continuously released from the catheter, thereby enhancing its clinical application in medicine. However, the composite nerve guide has poor electrical conductivity and is not easy to repair nerves.

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