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Application of aminooxyacetic acid to preparation of medicines for treating hepatocellular carcinoma

The technology of hepatocellular carcinoma and aminooxyacetic acid is applied in the application field of aminooxyacetic acid in the preparation of medicines for treating hepatocellular carcinoma, which can solve the problems such as no research reports on aminooxyacetic acid, achieve good proliferation of hepatoma cells, reduce modification horizontal effect

Active Publication Date: 2019-06-07
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

At present, some studies have reported that aminooxyacetic acid can selectively inhibit the growth of glioma and breast cancer cells, but so far there has been no research report on aminooxyacetic acid in the treatment of hepatocellular carcinoma

Method used

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  • Application of aminooxyacetic acid to preparation of medicines for treating hepatocellular carcinoma
  • Application of aminooxyacetic acid to preparation of medicines for treating hepatocellular carcinoma
  • Application of aminooxyacetic acid to preparation of medicines for treating hepatocellular carcinoma

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Embodiment Construction

[0017] In order to make the purpose, technical solution and advantages of the present invention more clear, the research on the activity of aminooxyacetic acid in treating hepatocellular carcinoma will be described in detail below with reference to the accompanying drawings.

[0018] 1. The inhibitory effect of aminooxyacetic acid on the modification of oxygen-linked N-acetylglucosamine in human liver cancer cells

[0019] The human liver cancer cell line PLC / PRF / 5 cells in the logarithmic growth phase were spread on a 6cm culture dish at a density of 70%. After the cells adhered to the wall, they were divided into the PLC / PRF / 5 group and the AOA group. The AOA group was added with 0.5mM AOA. After incubation for 24 hours, the two groups of cells were collected, the total protein was extracted, and the level of oxygen-linked N-acetylglucosamine modification of the cells was detected by using a broad-spectrum anti-O-GlcNAc antibody and Western Blot.

[0020] The result is as f...

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Abstract

The invention discloses an application of aminooxyacetic acid to preparation of medicines for treating hepatocellular carcinoma. Research results indicate that the aminooxyacetic acid can significantly reduce the modification level of O-N-acetylglucosamine of liver cancer cells, can show favorable liver cancer cell proliferation, invasion and transfer restraining effects, and can be used for developing new medicines for treating the hepatocellular carcinoma.

Description

technical field [0001] The present invention relates to a new application of substances, in particular to the application of aminooxyacetic acid (AOA) in the preparation of medicines. Background technique [0002] Liver cancer is one of the most common malignant gastrointestinal tumors. Among them, hepatocellular carcinoma (HCC) accounts for about 90% of liver cancers worldwide and is usually diagnosed at an advanced stage. Current treatment options are still limited and the cause of death in 90% of patients It's cancer cells that have metastasized. Although there are many traditional treatment methods for liver cancer, such as surgery, intervention, chemotherapy, radiotherapy, liver transplantation, etc., less than 30% of patients can receive curative treatments such as surgery or liver transplantation, and the postoperative recurrence and metastasis rates are very high , most of the remaining patients are mostly advanced patients, who have lost the chance of surgery or li...

Claims

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Application Information

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IPC IPC(8): A61K31/195A61P35/00
Inventor 唐霓汪凯黄爱龙夏杰向进庹琳潘璇明刘芮苟冬梅
Owner CHONGQING MEDICAL UNIVERSITY
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