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Medicinal PVC (Polyvinyl Chloride) hard sheet and production process thereof

A hard sheet and antistatic agent technology, applied in the field of pharmaceutical PVC hard sheet and its production process, can solve problems such as high surface resistance, drug pollution, and quality decline of PVC hard sheet, so as to enhance antistatic performance and increase antibacterial rate , to avoid the effect of bacterial contamination of drugs

Inactive Publication Date: 2019-05-28
ZHEJIANG TIANCHENG MEDICAL PACKING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since PVC is an insulating material, its surface resistance is extremely high, so it is easy to form a large amount of static electricity when it rubs against the roller shaft in the production process. On the one hand, there are likely to be production safety problems. The quality is degraded, and it is easy to cause pollution to the medicine, which needs to be improved

Method used

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  • Medicinal PVC (Polyvinyl Chloride) hard sheet and production process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A pharmaceutical PVC hard sheet, comprising the following parts by weight:

[0049] 80 parts of PVC;

[0050] 10 copies of EVOH, model L171B, purchased from Kuraray, Japan;

[0051] 5 copies of PE-g-MAH, model TY 1052H, purchased from Dow in the United States;

[0052] Acetyl tri-n-butyl citrate 3 parts;

[0053] 2 parts of stabilizing agent, and stabilizing agent comprises cerium stearate, zinc stearate and pentaerythritol that mass ratio is 2:2:1;

[0054] 6 parts of antistatic agent;

[0055] 0.4 parts of lubricant;

[0056] Antibacterial powder 4 parts.

[0057] The preparation process of the antistatic agent is as follows; in parts by weight, first mix 4 parts of dodecylamine, 16 parts of epichlorohydrin, and 160 parts of methanol and continue to stir for 4 hours, then add 18 parts of TMHDA, heat up to 55 ° C, and react for 10 hours , dialyzed to obtain a reaction solution, and finally vacuum-dried to obtain an antistatic agent.

[0058] The preparation proces...

Embodiment 2

[0069] A pharmaceutical PVC hard sheet, comprising the following parts by weight:

[0070] PVC 85 parts;

[0071] 15 copies of EVOH, model L171B, purchased from Kuraray, Japan;

[0072] 7 copies of PE-g-MAH, model TY 1052H, purchased from Dow in the United States;

[0073] Acetyl tri-n-butyl citrate 5 parts;

[0074] 4 parts of stabilizing agent, and stabilizing agent comprises cerium stearate, zinc stearate and pentaerythritol that mass ratio is 2:2:1;

[0075] 8 parts of antistatic agent;

[0076] 0.8 parts of lubricant;

[0077] Antibacterial powder 6 parts.

[0078] The preparation process of the antistatic agent is as follows; in parts by weight, first mix 7 parts of dodecylamine, 20 parts of epichlorohydrin, and 180 parts of methanol and continue to stir for 5 hours, then add 20 parts of TMHDA, heat up to 60 ° C, and react for 12 hours , dialyzed to obtain a reaction solution, and finally vacuum-dried to obtain an antistatic agent.

[0079] The preparation process...

Embodiment 3

[0090] A pharmaceutical PVC hard sheet, comprising the following parts by weight:

[0091] PVC 82 parts;

[0092] 12 copies of EVOH, model L171B, purchased from Kuraray, Japan;

[0093] 6 copies of PE-g-MAH, model TY 1052H, purchased from Dow in the United States;

[0094] Acetyl tri-n-butyl citrate 4 parts;

[0095] 3 parts of stabilizing agent, and stabilizing agent comprises cerium stearate, zinc stearate and pentaerythritol that mass ratio is 2:2:1;

[0096] 7 parts of antistatic agent;

[0097] Lubricant 0.6 parts;

[0098] Antibacterial powder 5 parts.

[0099] The preparation process of the antistatic agent is as follows; in parts by weight, first mix 6 parts of dodecylamine, 18 parts of epichlorohydrin, and 170 parts of methanol and continue to stir for 4.5 hours, then add 19 parts of TMHDA, heat up to 58 ° C, and react After 11 hours, dialyze to obtain the reaction solution, and finally vacuum-dry to obtain the antistatic agent.

[0100] The preparation process...

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Abstract

The invention discloses a medicinal PVC (polyvinyl chloride) hard sheet and a production process thereof. The medical PVC hard sheet comprises the following raw materials in parts by weight: 80 to 85parts of PVC, 10 to 15 parts of EVOH (Ethylene-Vinyl Alcohol), 5 to 7 parts of PE-g-MAH (Polyethylene-grafted-Maleic Anhydride), 3 to 5 parts of a plasticizer, 2 to 4 parts of a stabilizer, 6 to 8 parts of an antistatic agent and 0.4 to 0.8 part of a lubricant. The production process of the medicinal PVC hard sheet comprises the following steps of step 1, blending: firstly, mixing and uniformly stirring the 80 to 85 parts of PVC, the 10 to 15 parts of EVOH and the 5 to 7 parts of PE-g-MAH, then pouring into an extruder, extruding to form a strip, and then carrying out water cooling, granulation and drying, to obtain a blended particle; step 2, molding: firstly mixing and uniformly stirring the blended particle, the 3 to 5 parts of the plasticizer, the 3 to 4 parts of the stabilizer, the 6to 8 parts of the antistatic agent, the 0.4 to 0.8 part of the lubricant and 4 to 6 parts of antibacterial powder, then pouring into the extruder, extruding, then calendaring to form a sheet, controlling a thickness to be 0.15 mm to 0.6 mm, subsequently, cooling for forming, and finally, trimming and rolling. The medicinal PVC hard sheet has excellent barrier property, antistatic property and antibacterial property, and is applicable to medicine packaging.

Description

technical field [0001] The invention relates to packaging materials, in particular to a pharmaceutical PVC hard sheet and its production process. Background technique [0002] At present, in pharmaceutical packaging, solid oral preparations such as pills, capsules, and tablets are generally packaged in blister packs. Blister packaging materials include medicinal PVC hard sheet and medicinal aluminum foil. The PVC hard sheet forms multiple cavities for placing medicines through vacuum foaming or molding processes, and then seals the cavities with aluminum foil heat sealing. When in use, the required medicine can be taken out by piercing the aluminum foil with a finger. [0003] PVC hard sheet refers to a packaging material that meets the pharmaceutical requirements produced by extrusion, calendering and other processing methods using polyvinyl chloride resin as raw material and adding certain processing aids. It has no wrinkles, excellent transparency, thickness Uniform, go...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L27/06C08L23/08C08L51/06C08L71/02C08K5/00C08K5/11C08K5/098C08K5/053C08G65/26C08G65/333C08J5/18
Inventor 瞿忠忠
Owner ZHEJIANG TIANCHENG MEDICAL PACKING
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