Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition and its application

A composition and medicine technology, applied in the field of pharmaceutical compositions, can solve the problems of poor effect, large dosage, large side effects, etc., and achieve the effect of enhancing the original effect and reducing the plaque area

Active Publication Date: 2021-04-02
江苏海钥医药科技有限公司
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the prior art, the therapeutic effect of combined medication is not good, the dosage is large, and there are relatively large side effects.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition and its application
  • Pharmaceutical composition and its application
  • Pharmaceutical composition and its application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] And the preparation method of the above-mentioned dosage forms can be prepared by using known methods, for example, by using conventional mixing, granulating, coating, dissolving or freeze-drying processes. If necessary, the mixture or granules can be processed, after adding suitable auxiliary substances, to form tablets or cores of coated tablets.

[0029] While using the pharmaceutical pack, its dosage depends on various factors, such as administration mode, mammal species, age and / or individual condition.

[0030] The embodiment of the present invention also provides an application of the above-mentioned pharmaceutical composition or the above-mentioned pharmaceutical package in the preparation of a drug for treating atherosclerosis.

Embodiment 1

[0033] The present embodiment provides a kind of pharmaceutical composition, and it comprises following composition: berberine and Ilexin A. And the mass ratio of berberine and hollyn A is 2:1.

[0034] This embodiment also provides a medicine pack, which is a compound tablet of berberine catechin A, and the content of the pharmaceutical composition in the medicine pack is 51.7%. Its composition is as follows Table 1.

[0035] Table 1 Composition list

[0036] berberine 100.0mg Ilexin A 50.0mg compressible starch 120.0 mg Cyclodextrin 10.0mg Sodium carboxymethyl starch 10.0mg Magnesium stearate 0.6mg

[0037] The preparation method of the compound tablet is as follows: put berberine and cyclodextrin into a mortar and mix uniformly, add carboxymethyl starch sodium in turn, compressible starch and mix uniformly, finally add Ilexin A and mix uniformly, granulate , add magnesium stearate, mix well, and press into tablets.

Embodiment 2

[0039] The present embodiment provides a kind of pharmaceutical composition, and it comprises following composition: berberine and Ilexin A. And the mass ratio of berberine and hollyn A is 1:2.

[0040] This embodiment also provides a medicine pack, which is a compound tablet of berberine catechin A, the content of the pharmaceutical composition in the medicine pack is 46.0%, and its composition is shown in Table 2.

[0041] Table 2 Composition list

[0042] berberine 50mg Ilexin A 100mg microcrystalline cellulose 150mg Cyclodextrin 10mg Sodium carboxymethyl starch 15mg Micropowder silica gel 1mg

[0043] The preparation method of the compound tablet is as follows: put berberine and cyclodextrin into a mortar and mix evenly, then add sodium carboxymethyl starch, microcrystalline cellulose, and micropowder silica gel, mix evenly, and finally add hollylicin A and mix evenly , the powder can be compressed into tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of pharmacy, and particularly relates to a pharmaceutical composition and application thereof. The pharmaceutical composition comprises active components including berberine and ilicin A. The pharmaceutical composition aims to cooperatively treat atherosclerosis and remarkably reduce the aorta plaque area, and can enhance the inhibition effect of low density lipoprotein at the same time.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a pharmaceutical composition and its application. Background technique [0002] Atherosclerosis is a chronic inflammatory disease characterized by the deposition of atheromatous plaques on the vessel wall and resulting in progressive thickening of the arterial wall and narrowing of the lumen. Atherosclerosis eventually leads to coronary artery disease, stroke, peripheral artery disease, and kidney failure, among others. Endothelial injury is considered to be the initial event of atherosclerosis, and circulating monocytes are recruited to the injured area to differentiate into macrophages, which phagocytize lipids in large quantities, resulting in lipid deposition and local plaque formation; Phage cells release IL-1β, IL-6 and TNF-α, etc., increase the recruitment of macrophages, T cells, etc., and aggravate the formation of plaques. Smooth muscle cells migrate to cover the damaged area a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61P9/10A61K31/4375
Inventor 刘畅王媛媛祁明明孙云
Owner 江苏海钥医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com