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Double-drug albumin nanoparticles and preparation technology

A technology of albumin nanoparticles and albumin, which is applied in the field of albumin-loaded double-drug nanoparticles and the preparation process, to achieve the effects of reducing toxic and side effects, improving anti-tumor effect, and good stability

Inactive Publication Date: 2019-05-28
LIAOCHENG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, drug-loaded nanoparticles may accumulate at tumor sites due to secondary enhanced permeability and retention (EPR) effects

Method used

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  • Double-drug albumin nanoparticles and preparation technology
  • Double-drug albumin nanoparticles and preparation technology
  • Double-drug albumin nanoparticles and preparation technology

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Embodiment 1

[0031] Embodiment 1 The preparation process of a kind of double-drug albumin nanoparticles provided by the present invention is as follows: (1) configure paclitaxel and resveratrol stock solution; (2) prepare BSA stock solution; (3) prepare double-drug Albumin nanoparticles; as follows:

[0032] Prepare a 7 mg / mL stock solution of albumin with three times water. Prepare a mixed solution of paclitaxel and resveratrol dissolved in acetone, with a total drug concentration of 10 mg / mL;

[0033] Add the drug mixture dropwise to the constantly stirring albumin stock solution, continue stirring for 10 min, and remove the acetone by rotary evaporation. High-pressure homogenization several times to obtain double-drug albumin nanoparticles.

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Abstract

The invention provides paclitaxel / resveratrol albumin nanoparticles and a preparation technology. The preparation technology comprises the following steps: (1) preparing a paclitaxel and resveratrol storage solution; (2) preparing an albumin storage solution; (3) preparing double-drug albumin nanoparticles. According to the paclitaxel / resveratrol albumin nanoparticles, an anti-cancer drug paclitaxel and a bioactive substance resveratrol are combined to be administrated, so that the toxic side effect can be reduced and the anti-cancer effect is improved; the prepared double-drug albumin nanoparticles have the encapsulation efficiency of 99 percent and have good stability; the double-drug albumin nanoparticles provided by the invention can be released in sequence; the resveratrol is rapidlyreleased so that the effect of inhibiting P-gp is facilitated; a condition that the paclitaxel which is released subsequently is pumped out from tumor cells is avoided, so that the cytotoxicity on thedrug-resisting tumor cells is increased; an in-vitro cytotoxicity experiment of the double-drug albumin nanoparticles provided by the invention proves that the drug resistance of the tumor cells canbe reversed, and a cooperative anti-tumor effect of the paclitaxel and the resveratrol in the double-drug nanoparticles is realized.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to an albumin-loaded double-drug nanoparticle and a preparation process. Background technique [0002] Cancer, together with cardiovascular and cerebrovascular diseases and accidents, is one of the leading causes of death that seriously threatens human life worldwide. While most cancer-related deaths are due to resistance of metastatic tumors to chemotherapy, multidrug resistance (MDR) is considered a major obstacle to cancer treatment. Multidrug resistance leads to the failure of chemotherapy in many cancers, including breast, ovarian, lung, gastrointestinal, and hematological malignancies. Despite multiple attempts to overcome MDR, the treatment of drug-resistant cancer remains an important medical problem. [0003] The basic strategy for the treatment of drug-resistant tumors is drug combination. Combination therapy has long been used as standard first-l...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/42A61K31/337A61K31/05A61P35/00
Inventor 刘敏蔡畅赵燕娜韩军
Owner LIAOCHENG UNIV
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