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Hypoglycemic substance aiming at hyperglycemia during pregnancy, preparation method and application of substance

A technology of substances and liquid substances, applied in the direction of medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc., can solve problems such as side effects

Inactive Publication Date: 2019-05-24
徐爽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many drugs that can treat general hyperglycemia. Although these drugs also have a certain degree of side effects, for patients with general hyperglycemia, the benefits of the drugs outweigh the side effects, so they can be used alone or in combination

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prepared by solvent extraction Hevea brasiliensis For the fat-soluble part of the seeds, the solvent selected for extraction is No. 6 solvent. 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. Then, after the seed kernels are puffed, they are put into a sealed leaching container, and 2 times the weight of solvent is added. Under the condition of 55°C (lower than the boiling point of the solvent) and normal pressure, the material and the solvent are stirred and mixed to allow the material to fully contact with the solvent. Then let it stand for precipitation, drain the solvent, and then let the solvent volatilize under 120°C (higher than the boiling point of the solvent) and 100Pa vacuum conditions, leaving 18kg of liquid substance which is the substance of the present invention.

[0027] Forty patients with hyperglycemia during pregnancy at 20-26 weeks of pregnancy were recruited and ran...

Embodiment 2

[0030] Prepared by mechanical extrusion Hevea brasiliensis For the fat-soluble part of the seeds, the selected method is the static extrusion method. 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. Seed kernel material is heated to 80-100 DEG C, then through static extrusion, the pressure is 50MPa, extruding 12kg liquid substance is the substance of the present invention.

[0031] Forty patients with hyperglycemia during pregnancy were recruited and randomly divided into two groups, 20 people in each group. The first group (experimental group) took orally the health food made of the substance of the present invention, and the dosage was 10g / day (based on the amount of the substance of the present invention in the medicine); the second group (the control group) took perilla seed oil orally, and the oral dose 10 g / day. Tested 30 days after oral administration.

[0032] The detection index is ...

Embodiment 3

[0034] Prepared by mechanical extrusion Hevea brasiliensis For the fat-soluble part of the seed, the selected method is the screw extrusion method. 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then undergoes dynamic screw extrusion. The screw extrusion time is about 45 seconds, and 15 kg of liquid material is extruded, which is the material of the present invention.

[0035] Pregnant woman C, aged 35, experienced gestational hyperglycemia in the 24th week of pregnancy, and then began to adjust her diet, and ate foods made of fat-soluble substances extracted from corn germ (corn germ oil), with a consumption of 20 grams per day (calculated as corn germ oil). After 2 weeks of treatment with this regimen, blood sugar continued to rise.

[0036] From the 26th week, pregnant women stop eating food made of fat-soluble substances (corn germ oil...

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Abstract

The invention discloses a hypoglycemic substance aiming at hyperglycemia during pregnancy and an application of the substance. The substance is a fat-soluble part of a seed of a plant Hevea brasiliensis, and is obtained through a mechanical extrusion method, a solvent extraction method, a grinding water substitution method, a supercritical extraction method and other methods of the dried and shelled seeds. The substance can be applied to medicines, health foods, and foods, and is used for reducing blood sugar of patients with hyperglycemia during pregnancy. Patients with hyperglycemia during pregnancy can obtain a good hypoglycemic effect by taking or eating drugs, health food and food added with the substance daily; and the substance has no side effect, and is very safe for mothers and infants.

Description

technical field [0001] The invention discloses a hypoglycemic substance for hyperglycemia during pregnancy and an application thereof, belonging to the fields of medicine and food. Background technique [0002] There are two types of diabetes in pregnant women during pregnancy. One is diabetes diagnosed before pregnancy, which is called "diabetes combined with pregnancy"; the other is normal glucose metabolism or potential impaired glucose tolerance before pregnancy, which occurs or is diagnosed during pregnancy This type of diabetes is called gestational hyperglycemia, also known as gestational diabetes. Hyperglycemia during pregnancy accounts for more than 80% of pregnant women with diabetes, and the incidence rate is reported to be 1% to 14% in various countries in the world. In my country, the incidence rate is 1% to 5%. Most patients with hyperglycemia during pregnancy can return to normal after delivery, but the chances of suffering from type II diabetes will increase...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61P3/10A61P15/00
Inventor 徐爽
Owner 徐爽
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