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Oral care compositions for promoting gum health

A technology of oral care and composition, which is applied in the field of oral care composition, can solve problems such as adverse side effects, achieve the effect of promoting gum health, improving the beneficial effect of gum health, and stabilizing product quality

Pending Publication Date: 2019-05-21
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] This in turn may be disadvantageous for several reasons, including limitations on the efficacy of oral care products due to maximum safe upper limits or cost constraints of using ever increasing amounts of these antimicrobials, and / or may be associated with higher levels of these antimicrobials associated adverse side effects

Method used

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  • Oral care compositions for promoting gum health
  • Oral care compositions for promoting gum health
  • Oral care compositions for promoting gum health

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to 10

[0161] Examples 1 to 10 are dentifrice compositions as shown below, wherein the amounts of the components are in % by weight. They can be suitably prepared by conventional methods selected by the formulator. Examples 1 to 6 are preparations of the present invention according to the present invention, respectively prepared with two concentrations of stannous ion source (such as stannous chloride) and a single antifibrinolytic agent (such as TA, EACA or PAMBA). Example 7 is a formulation of the invention prepared with stannous chloride and two antifibrinolytic agents such as TA and EACA. At the same time, Comparative Formulation Examples 8 to 10 were prepared. Example 8 was prepared without a source of stannous ions, Example 9 was prepared without an antifibrinolytic agent, and Example 10 was prepared without any components. All compositions were prepared from mixtures of the ingredients in Tables 1 and 2 in the proportions indicated.

Embodiment 1 to 7

[0163]

[0164]

[0165] Table 2: Comparative Composition Examples 8 to 10

[0166]

Embodiment 11

[0167] Example 11 - Assay for Measuring Improved Gingival Wound Healing in the Oral Mouth

[0168] The following assays were used to determine the improvement in gingival wound healing in the oral cavity for oral care compositions of the invention and control oral care compositions. This assay involves gentle probing of the gingival crevices to assess for bleeding. Gingivitis was assessed according to Mazza's Papapilla Bleeding Index on Probing ("PBI", with a modification of Muhlemann, H.R.: J. Prev. Dent. 1977; 4:6), otherwise known as the "Mazza Index", to determine Number of bleeding sites (defined by Mazza, 1981). For this measurement, a maximum of 56 sites on the medial and distal lingual surface of each tooth were probed. Place the probe in the gingival sulcus to a depth of approximately 0.5 mm to 1.0 mm and scan the tip of the interdental papilla from its insertion point along the soft tissue direction of the sulcus. Scan all of the face or tongue in each quadrant ...

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Abstract

Oral care compositions comprising an antifibrinolytic agent (e.g., tranexamic acid) and stannous ion source are provided for promoting Gum Health of a consumer.

Description

technical field [0001] The present invention relates to oral care compositions comprising a source of stannous ions and an antifibrinolytic agent for promoting gum health in consumers. In particular, such oral care compositions are useful for improving gingival wound healing and improving the reduction of bacterial activity in the consumer's mouth. Background technique [0002] Gum diseases such as gingivitis and / or periodontitis cause acute and chronic inflammation of the gums in the oral cavity. "Gingivitis" is a milder form of the disease. Symptoms of gingivitis may include: bleeding gums; and red, swollen, or puffy gums. If left untreated, gingivitis can develop into "periodontitis." With periodontitis, the gums break away from the teeth and create spaces called "periodontal cavities," which can become infected with pathogenic bacteria. Bacteria exist as biofilms on tooth root surfaces. Bacteria in the biofilm may attack the gums and the underlying alveolar bone, wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/44A61K8/19A61Q11/00
CPCA61K8/20A61K8/44A61Q11/00
Inventor R·斯特兰德徐秀军苏旸史运明
Owner THE PROCTER & GAMBLE COMPANY
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