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Application of cardamine and extracts thereof in preparing medicine for preventing or treating arrhythmia

A technique for arrhythmia and broken rice camelina, which is applied in the field of biomedicine, can solve the problems of incomplete research on chemical substances, insufficient pharmacological activity and other problems, achieves prevention or treatment of arrhythmia, reduces the incidence of ventricular fibrillation, and the preparation method is scientific and reasonable. Effect

Active Publication Date: 2019-05-17
广州博济新药临床研究中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the research on the chemical constituents of broken rice chestnuts mainly focuses on selenium polysaccharides, selenoproteins, flavonoids, volatiles and other substances, and the research on pharmacological activity mainly focuses on the immune and antioxidant activities of polysaccharides and proteins. The research on other chemical substances in chestnut is not complete enough, and the pharmacological activity is also not systematic enough

Method used

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  • Application of cardamine and extracts thereof in preparing medicine for preventing or treating arrhythmia
  • Application of cardamine and extracts thereof in preparing medicine for preventing or treating arrhythmia

Examples

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Effect test

Embodiment 1

[0020] A kind of embodiment of the preparation method of broken rice chestnut extract of the present invention, comprises the following steps:

[0021] (1) Alcohol extraction: Crushed rice chestnuts are crushed to make coarse powder, the coarse powder is extracted with 8 times the amount of 95% ethanol under reflux for 3 hours, the extract is filtered, and 6 times the amount of 95% ethanol is added for the second time to extract under reflux for 3 hours, and the extract is filtered , concentrated under reduced pressure at 40°C to obtain a concentrated solution;

[0022] (2) Extraction: add an equal volume of water-saturated n-butanol to the concentrated solution obtained in step (1), extract three times, collect the n-butanol layer, concentrate under reduced pressure, and dry to obtain the extract of the broken orchidna.

Embodiment 2

[0024] A kind of embodiment of the preparation method of broken rice chestnut extract of the present invention, comprises the following steps:

[0025] (1) Alcohol extraction: Crushed rice chestnuts are crushed to make coarse powder, the coarse powder is extracted with 12 times the amount of 70% ethanol under reflux for 3 hours, the extract is filtered, and 10 times the amount of 70% ethanol is added for the second time to extract under reflux for 3 hours, and the extract is filtered , concentrated under reduced pressure at 60°C;

[0026] (2) Extraction: add an equal volume of water-saturated n-butanol to the concentrated solution obtained in step (1), extract three times, collect the n-butanol layer, concentrate under reduced pressure, and dry to obtain the extract of the broken orchidna.

Embodiment 3

[0028] A kind of embodiment of the preparation method of broken rice chestnut extract of the present invention, comprises the following steps:

[0029] (1) Alcohol extraction: Crushed rice chestnuts are crushed to make coarse powder, the coarse powder is extracted with 10 times the amount of 50% ethanol under reflux for 3 hours, the extract is filtered, and 8 times the amount of 50% ethanol is added for the second time to extract under reflux for 3 hours, and the extract is filtered , concentrated under reduced pressure at 50°C;

[0030] (2) Extraction: Add an equal volume of water-saturated n-butanol to the concentrated solution obtained in step (1), extract three times, collect the n-butanol layer, concentrate under reduced pressure, and dry to obtain the extract CDL1 .

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Abstract

The invention relates to application of cardamine and extracts thereof in preparing medicine for preventing or treating arrhythmia, and belongs to the technical field of biomedical medicine. The cardamine and the extracts thereof can effectively prevent or treat the arrhythmia, and meanwhile the ventricular fibrillation rate and the duration of the arrhythmia are shortened; the preparation methodof the cardamine and the extracts thereof are scientific, reasonable, simple in process and high in operability.

Description

technical field [0001] The invention relates to the application of the broken rice chestnut and its extract in the preparation of medicines for preventing or treating arrhythmia, and belongs to the technical field of biomedicine. Background technique [0002] Cardamine hirsuta L. is a 1 to 2-year-old herbaceous plant of the genus Cardamine hirsuta L. in the genus Cardamine hirsuta L., which mostly grows in hillsides, roadsides, wastelands and cultivated grasses below 1000 meters above sea level. It is wild all over the country. It is also widely distributed in temperate regions of the world. [0003] At present, the research on the chemical constituents of broken rice chestnuts mainly focuses on selenium polysaccharides, selenoproteins, flavonoids, volatiles and other substances, and the research on pharmacological activity mainly focuses on the immune and antioxidant activities of polysaccharides and proteins. The research on other chemical substances in chestnut is not co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61P9/06
Inventor 马仁强王宁丁钟泓玲周清王廷春马艺华
Owner 广州博济新药临床研究中心有限公司
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