Method and system for preparing medicinal liposomes

Abstract

The invention relates to the field of medicinal preparations, and especially relates to a method for preparing medicinal liposomes. The method includes the following steps: adjusting liquid carbon dioxide to a supercritical state; dissolving supercritical carbon dioxide in one pipeline with a core material drug, dissolving the supercritical carbon dioxide in the other pipeline with a wall materialsolution, and making the temperature of the supercritical carbon dioxide dissolved with the wall material solution being higher than that of the supercritical carbon dioxide dissolved with the core material drug; introducing the supercritical carbon dioxide dissolved with the core material drug after temperature adjusting into a granulation kettle from the upper part, introducing the supercritical carbon dioxide dissolved with the wall material solution into the granulation kettle from the lower part, and performing liposome granulation, wherein the pressure of the supercritical carbon dioxide dissolved with the core material drug and the pressure of the supercritical carbon dioxide dissolved with the wall material solution are greater than that in the granulation kettle; and collecting encapsulated liposomes. The method reduces the agglomeration of core material particles and the probability of the multiple embedding of the liposomes, and enhance the encapsulation rates of the liposomes.

Description

technical field [0001] The present application relates to the field of pharmaceutical preparations, in particular to a method and system for preparing pharmaceutical liposomes. Background technique [0002] Liposome is an artificial membrane. When amphiphilic molecules (such as phospholipids and sphingolipids) are dispersed in the water phase, the hydrophobic tails of the molecules tend to gather together to avoid the water phase, while the hydrophilic heads of the molecules are exposed to the water. Phase, the formation of closed vesicles with a bilayer structure. Liposomes can be used for transgenes or drugs, and liposome drugs used for drugs refer to microvesicles formed by encapsulating drugs in lipid bilayers. Specifically, liposome drugs use the feature that liposomes can fuse with cell membranes to deliver drugs into cells. [0003] In the prior art, the method for producing liposomes is generally to feed the configured emulsion into a supercritical kettle according...

AI Technical Summary

Problems solved by technology

However, in the prior art, it is easy to cause the aggregation of core material particles and the repeated embedding of liposomes in the process of producing liposomes, which affects the embedding effect and embedding rate of liposomes.

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