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Method and system for providing buffer solutions

A buffer and solution technology, applied in the field of product solutions and buffers, to reduce manufacturing costs and eliminate risks

Pending Publication Date: 2019-05-03
隆扎有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These processing steps may require large quantities of expensive processing solutions to maintain sterility and ensure that the biological product retains its activity

Method used

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  • Method and system for providing buffer solutions
  • Method and system for providing buffer solutions
  • Method and system for providing buffer solutions

Examples

Experimental program
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Embodiment 1

[0268] Example 1. Treatment Solution Components for Treatment of Biological Products According to the Disclosure.

[0269] Tables 6-9 list the components, ingredient concentrations, and buffer requirements of a treatment solution for a biological product prepared in a bioreactor according to the present disclosure. Buffers A-L in Tables 7-9 correspond to buffers A-L identified in Table 6.

[0270] Bioprocess vessels can be used to contain the following buffers: Tris, Tris base, Tricine, HEPES, MOPS, PIPES, TAPS, bicine, BES, TES, Cacodylate, MES, Acetate, MKP, ADA, ACES, Glycine amide, acetaminoglycine, acetic acid, citric acid, glycine, glycine glycinate, sodium phosphate salt, ethanol, hydrochloric acid, sodium hydroxide, guanidine chloride, guanidine hydrochloride, sodium chloride, or any combination of these buffers or other buffers.

[0271]Tris is also known as tris(hydroxymethyl)aminomethane. HEPES is also known as 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid...

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Abstract

A method for delivering a processing solution includes providing a concentrated processing solution in a bioprocess container, the concentrated processing solution being produced at a first site. Themethod also includes combining the concentrated processing solution with a biopolymer containing solution produced in a bioreactor at a second site different from the first site. In some embodiments,the processing solution is a buffer for processing products of cells cultured in a bioreactor. A system and a pharmaceutical production facility for carrying out the method are also provided.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to US Provisional Patent Application Serial No. 62 / 370,041, filed August 2, 2016, which is incorporated herein by reference in its entirety for all purposes. field of invention [0003] The present disclosure relates to solutions, eg, buffers, for use in treating products of cells cultured in bioreactors. Background of the invention [0004] Bioreactors are used to produce large quantities of desired biological products. After growing the cells in the bioreactor to produce the bioproduct, subsequent steps are performed to isolate and concentrate the bioproduct. These processing steps may require large quantities of expensive processing solutions to maintain sterility and ensure that the biological product retains its activity. There is a need for a more cost-effective way of producing solutions for processing biological products. Summary of the invention [0005] Asp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00B01L3/00
CPCC12M37/00C12M23/44C12M29/00C12M41/32C12M43/00C12M41/36B67D7/0294
Inventor T.威尔金斯
Owner 隆扎有限公司
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