Comprehensive quality evaluation method based on multi-active-component detection of radix scrophulariae

Abstract

The invention, which belongs to the technical field of traditional Chinese medicine quality detection, discloses a comprehensive quality evaluation method based on multi-active-component detection ofradix scrophulariae. The method comprises: step one, measuring a content; to be specific, measuring contents of harpagide and harpagoside to determine whether the content of radix scrophulariae meetsa content requirement in the "Chinese Pharmacopoeia"; step two, evaluating fingerprint spectrum similarity; to be specific, identifying specific chromatograms of aucubin, harpagide, ferulic acid, angoroside C, harpagoside, and cinnamic acid by means of similarity analysis to realize identification of authenticity of the quality of the radix scrophulariae and evaluation of the homogeneity and stability of the quality of the radix scrophulariae; and S3, carrying out comprehensive scoring; to be specific, establishing a weighted comprehensive evaluation system to evaluate the quality of the radixscrophulariae comprehensively. According to the invention, the content of the cinnamic acid is measured and the specific chromatograms of main active components of the radix scrophulariae are identified; and comprehensive quality evaluation is carried out by carrying out weighted grading on detection components, so that the quality of the radix scrophulariae can be evaluated accurately.

Description

technical field [0001] The invention belongs to the technical field of quality detection of traditional Chinese medicines, and in particular relates to a comprehensive quality evaluation method based on the detection of multiple active components of Scrophulariaceae. Background technique [0002] Scrophulariaceae is the dry root of the Scrophulariaceae plant Scrophularianingpoensis Hemsl. Excavate when the stems and leaves wither in winter, remove rhizomes, young shoots, fibrous roots and sediment, sun or dry until half-dry, stack for 3 to 6 days, and repeat several times until dry. Scrophulariaceae is a commonly used Chinese medicinal material, which was first recorded in "Shen Nong's Materia Medica" and listed as a middle grade. "Bielu of Famous Doctors" says: "Where are the rivers and valleys and injustice sentences born?". Scrophulariaceae Alias: Yuanshen, Wuyuanshen, Black Ginseng, Chongtai, Guizang, Zhengma, Deer Intestine, Xuantai, Zhuma, Fucao, Wild Sesame, Angelic...

AI Technical Summary

Problems solved by technology

[0021] Due to the wide application of Scrophulariae Scrophulariae, many curative effects, and complex components, the current "Chinese Pharmacopoeia" only contains the TLC identification and content determination methods of harpagoside and harpagoside, while ignoring the detection and quality assessment of other active ingredients , cannot accurately evaluate the product quality and curative effect of Scrophulariaceae, and guide clinical medication

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