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Sponge-derived meroterpenoid compounds as well as preparation method and application thereof

A compound and source technology, applied in the field of medicine, to achieve the effects of significant inhibitory activity, obvious inhibitory activity and simple preparation method

Active Publication Date: 2019-05-03
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, there has been no report on obtaining heteroterpene compounds from this genus sponge that have therapeutic effects on inflammation in transgenic zebrafish.

Method used

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  • Sponge-derived meroterpenoid compounds as well as preparation method and application thereof
  • Sponge-derived meroterpenoid compounds as well as preparation method and application thereof
  • Sponge-derived meroterpenoid compounds as well as preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0038] The preparation of embodiment 1 compound Septosone A

[0039] Get pre-frozen and chopped sponge sponge (wet weight 700g), use 95% ethanol (1L) cold soaking extraction 5 times respectively, each time for a week, combine the extracts, extracts are concentrated under reduced pressure to obtain the total extract, and the total The extract was suspended in water, then extracted 5 times with equal volumes of n-hexane and dichloromethane, the combined extracts were concentrated under reduced pressure to obtain n-hexane extract (2.4g), dichloromethane extract (3.2g) , LC-MS detected the presence of Septosone A in both extracts.

[0040] The above extract was separated by vacuum silica gel column chromatography, and petroleum ether-ethyl acetate gradient elution was used. According to the results of thin layer chromatography TLC analysis, a fraction containing sesquiterpene quinone compounds was obtained, and then Sephadex LH-20 gel The column further enriches the fraction, and...

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Abstract

The invention relates to the technical field of medicines, and discloses sponge-derived meroterpenoid compound Septosone A. The Septosone A has a chemical structural formula shown in the description.The invention also discloses a preparation method and application of the Septosone A. The compound Septosone A provided by the invention has very strong inhibitory activity on a NF-kappaB signal channel, and can inhibit formation and diffusion of transgenic zebrafish inflammation in vivo and be used for preparing anti-inflammatory and anti-tumor drugs.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to a sponge-derived heteroterpene compound Septosone A and its preparation method and application. Background technique [0002] The sponge is a low-level multicellular animal with a history of more than 500 million years of evolution. It has formed a unique chemical defense mechanism in the harsh competitive environment of the ocean, which can efficiently produce active substances, and discover novel structures from sponges every year. Active substances account for more than one-third of marine natural products. At present, 3 of the 7 marine drugs approved by the FDA in the United States are derived from sponges. Therefore, sponges have become an important source of marine drugs and have always been an important source of marine natural product chemistry. research hotspots. [0003] The stubborn sponge (Dysidea Septosa) is a sponge belonging to the class Demospongiae, Dic...

Claims

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Application Information

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IPC IPC(8): C07C49/753C07C45/78C07C45/79A61P29/00A61P35/00
Inventor 焦伟华林厚文桂语晗
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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