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Chinese traditional medicine granule for treating silicosis and preparation method of Chinese traditional medicine granule

A technology for traditional Chinese medicine granules and silicosis, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of high operation cost and mortality, difficult to find donors, and inability to effectively remove lung dust.

Inactive Publication Date: 2019-04-23
平措绕吉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drug treatment includes gram-silicon drug treatment. The current drug treatment mainly plays a role in relieving symptoms and cannot effectively remove lung dust. Nutritional treatment can be used to supplement nutrition in time, improve body resistance and appropriately increase the supply of trace elements, so as to treat silicosis. Patients themselves play an important role in regulating symptoms; there is also surgical treatment, which includes whole lung lavage. Lung lavage technology can effectively remove lung dust, but there are many problems such as high cost, patient pain, and many complications. Lung transplantation can also be used for treatment of middle and advanced patients when the drug treatment is not good. The successful effect of lung transplantation is the best, but there are problems such as high operation cost and mortality, and difficulty in finding donors.

Method used

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  • Chinese traditional medicine granule for treating silicosis and preparation method of Chinese traditional medicine granule
  • Chinese traditional medicine granule for treating silicosis and preparation method of Chinese traditional medicine granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Grind 10 parts of succulent grass, 10 parts of Suihua, 39 parts of longan longan, 7 parts of Liwu, 21 parts of Azhong, and 30 parts of licorice in the prescribed amount, pass through a 20-mesh sieve, and use it at 80 ° C. 40 parts of acetic acid were boiled for 0.5h and filtered;

[0026] (2) Heat and reflux the filter residue obtained in step (1) with 60 parts of 60% ethanol to extract twice, each time for 4 hours, filter, combine the filtrate, add 21 parts of bright salt in the prescribed amount, recover ethanol, and concentrate to density 1.2g / cm 3 ;

[0027] (3) In the concentrated solution obtained in step (2), add 52 parts of excipients in the prescription amount, the excipients are composed of 8 parts of carboxymethyl cellulose, 3 parts of talcum powder, 18 parts of pregelatinized starch, and 15 parts of lactose, After thorough mixing, granulation is carried out using rapid stirring technique.

Embodiment 2

[0029] (1) Grind 7 parts of succulent grass, 20 parts of Suihua, 43 parts of longan longan, 9 parts of Liwu, 15 parts of Azhong, and 58 parts of licorice in the prescribed amount, pass through a 40-mesh sieve, and use it at 100 ° C. 60 parts of acetic acid were boiled for 1h and filtered;

[0030] (2) Heat and reflux the filter residue obtained in step (1) with 80 parts of 60% ethanol to extract twice, each time for 4 hours, filter, combine the filtrate, add 25 parts of bright salt in the prescribed amount, recover ethanol, and concentrate to density 1.4g / cm 3 ;

[0031] (3) In the concentrated solution obtained in step (2), add 43 parts of excipients in prescription amount, the excipients are 25 parts of carboxymethyl cellulose, 1 part of talcum powder, 20 parts of pregelatinized starch, and 4 parts of lactose. After mixing, granulation is carried out using rapid stirring technique.

Embodiment 3

[0033] (1) Grind 19 parts of succulent grass, 32 parts of Suihua, 65 parts of longan longan, 15 parts of Liwu, 15 parts of Azhong and 47 parts of licorice in the prescribed amount, pass through an 80-mesh sieve, and use it at 110 °C 80 parts of acetic acid were boiled for 1 hour and filtered;

[0034] (2) Use 40 parts of the filter residue obtained in step (1) to heat and reflux extract twice with 60% ethanol for 4 hours each time, filter, combine the filtrate, add 32 parts of bright salt in the prescribed amount, recover the ethanol, and concentrate to The density is 1.3g / cm 3 ;

[0035] (3) In the concentrated solution obtained in step (2), add 32 parts of excipients in prescription amount, the excipients are 20 parts of carboxymethyl cellulose, 2 parts of talcum powder, 8 parts of pregelatinized starch, and 10 parts of lactose. After mixing, granulation is carried out using rapid stirring technique.

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Abstract

The invention aims at providing a Chinese traditional medicine granule for treating the silicosis and a preparation method of the Chinese traditional medicine granule. The Chinese traditional medicinegranule is prepared from, by weight, 7-20 parts of lancea tibetica, 10-32 parts of tronae, 38-65 parts of fructus piperis longi, 3-15 parts of herba ligulariae virgaurea, 15-38 parts of all grass ofblack saxifrage, 30-70 parts of radix glycyrrhizae, 10-32 parts of halite and 32-80 parts of pharmaceutic adjuvant. The Chinese traditional medicine granule has the advantages that the Chinese traditional medicine materials are subjected to acetic acid cooking to destroy the plant tissue structure to promote the dissolution of the effective components of the Chinese traditional medicine materials,reflux extraction is carried out twice with ethyl alcohol, so that the yield of the extraction of the effective components is higher, finally, the Chinese traditional medicine materials are preparedinto the Chinese traditional medicine granule, and the Chinese traditional medicine granule is slightly sweet in taste and is conducive to being taken by a patient; the Chinese traditional medicine granule can be used for treating unceasing cough and asthma, chest distress and palpitations caused by the silicosis, and can clear lung, eliminate phlegm and eliminate lung toxins.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine granule for treating silicosis and a preparation method thereof, and relates to the field of traditional Chinese medicine preparations. The traditional Chinese medicine granules prepared by the method can be used to treat endless cough, dyspnea, chest tightness and palpitation caused by silicosis. Background technique [0002] Silicosis is a systemic disease mainly caused by diffuse fibrosis of lung tissue caused by long-term inhalation of productive dust and retention in the lungs. Silicosis is the most serious occupational disease in the world. According to the National Health and Family Planning Commission's special survey on occupational diseases, silicosis and miner's pneumoconiosis are the most common silicosis, accounting for about 90% of the total number of silicosis, ranking first among occupational diseases. [000...

Claims

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Application Information

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IPC IPC(8): A61K36/808A61K9/16A61P11/00A61P11/14A61P11/06A61P11/10A61K33/00A61K33/14
CPCA61K9/1652A61K33/00A61K33/14A61K36/28A61K36/36A61K36/484A61K36/67A61K36/808A61K2236/333A61K2236/39A61P11/00A61P11/06A61P11/10A61P11/14A61K2300/00
Inventor 平措绕吉
Owner 平措绕吉
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