Method for selecting samples in lithium salt concentration monitor project

Abstract

The invention discloses a method for selecting samples in a lithium salt concentration monitor project, relating to the technical field of lithium salt concentration clinical diagnosis and monitor. The method comprises specific steps of S1, for a patient taking medicines regularly, after the patient takes medicines as normal at night, collecting monitor samples at a fixed time 12 hours later the next day, and dropping an additive to the collected monitor sample; S2, measuring lithium salt concentration of the collection samples separately, evaluating difference of different blood sampling manners and storage temperatures on lithium salt concentration, and providing an accurate detection report for the clinical test; and S3, selecting a proper sample collection tool, a sample additive, sample storage time and temperature according to a group with smallest difference with normal lithium index. The method avoids providing distorted test reports for clinical tests due to sample error of alaboratory, so that the test report for clinical treatment is more reliable, the risk of treating with lithium salt by the patient is minimized, and the treatment effect is maximized.

Description

technical field [0001] The invention discloses a sample selection method in a lithium salt concentration monitoring project, and specifically relates to the technical field of clinical diagnosis and monitoring of lithium salt concentration. Background technique [0002] In the treatment of psychiatric drugs, lithium salt is the first choice and gold standard of mood stabilizers in the treatment and prevention of relapse of bipolar disorder. It is also a mood stabilizer with clear suicide prevention effect. Both sexes reduce suicide risk. However, it was found that lithium salts also have different side effects during use, such as apathy, tremor, restlessness, chorea, ataxia, renal function damage, seizures, severe coma and even death. Because lithium salts are not bound to proteins and have a single clearance route (mainly excreted through the kidneys), the therapeutic dose of lithium salts (0.4-1.5mmol / L) is very close to the toxic dose (1.6mmol / L), and different drugs are...

AI Technical Summary

Problems solved by technology

[0003] Compared with other methods, the influence of the sample's own factors on the results of Li+ determination by ISE method is more complicated, which may cause the electrode to show distorted detection results