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Erythrocyte preservation fluid and preservation apparatus

A technology for preserving solution and red blood cells, applied in the field of blood transfusion testing, can solve the problems of browning of red blood cells, prolonged storage time of red blood cells, hemolysis, etc.

Inactive Publication Date: 2019-04-05
NINGBO AJCORE BIOSCIENCES INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current erythrocyte preservation solution generally uses ACD preservation solution, CPD preservation solution, etc. at home and abroad. These preservation solutions can prolong the preservation time of erythrocytes, but browning and hemolysis of erythrocytes appear after one month.

Method used

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  • Erythrocyte preservation fluid and preservation apparatus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prepare red blood cell preservation solution according to the following components and contents:

[0019] Adenine 0.4mg / ml, glucose 30mg / ml, sodium citrate 10mg / ml, sodium dihydrogen phosphate 0.04mg / ml, EDTA-3K content 2.0 mg / ml, sorbitol content 6 mg / ml, seaweed The sugar content is 6 mg / ml.

[0020] Prepare 1000ml red blood cell preservation solution with RNase-free purified water.

Embodiment 2

[0022] Prepare red blood cell preservation solution according to the following components and contents:

[0023] Adenine 0.6mg / ml, glucose 40mg / ml, sodium citrate 6mg / ml, sodium dihydrogen phosphate 0.02mg / ml, EDTA-3K content 1.5 mg / ml, EDDHA–Na content 0.8 mg / ml, cascara The sugar content is 10 mg / ml.

[0024] Prepare 1000ml red blood cell preservation solution with RNase-free purified water.

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PUM

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Abstract

The invention relates to an erythrocyte preservation fluid. The erythrocyte preservation fluid comprises the following components: 0.2-0.6mg / ml adenine, 20-50mg / ml glucose, 5-15mg / ml sodium citrate, 0.02-0.06mg / ml sodium dihydrogen phosphate, 1.0-3.0mg / ml anticoagulation agents, and 5-20mg / ml film protective agents, wherein the anticoagulation agents are selected from one or more of EDTA-3K and EDDHA salts. By the aid of the erythrocyte preservation fluid, the coagulability of erythrocytes in the preservation process can be reduced, erythrocyte preservation time can be prolonged, and erythrocyte hemolysis can be reduced.

Description

technical field [0001] The invention relates to the technical field of blood transfusion testing, in particular to a red blood cell preservation solution and a preservation device. Background technique [0002] The blood type serological test before blood transfusion is the most basic and important experimental item to ensure the safety of blood transfusion. Antigen-antibody reactions are inseparable from blood group serology experiments. At present, the antibody reagents used in blood group serology have already been commercialized and standardized in large quantities due to their convenient production and purification. As another essential component in the reaction system is red blood cells, the problems it faces as a reagent are much more complicated. First of all, the raw material of red blood cells must come from the human body and cannot be replaced by substances from other sources. Secondly, the life span of red blood cells is short, with an average life span of 120...

Claims

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Application Information

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IPC IPC(8): A01N1/02
CPCA01N1/0226A01N1/0242
Inventor 周杰锋王德明
Owner NINGBO AJCORE BIOSCIENCES INC
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