Amphiphilic hydroxyl magnetic bead, and preparation method and application thereof

An amphiphilic and hydroxyl technology, applied in the field of materials, can solve the problems of difficult to precisely control the hydrophobicity strength and hydrophobicity density, difficult to control the surface characteristics of magnetic beads, etc., to achieve less damage, mild reaction conditions, and particle size distribution. uniform effect

Inactive Publication Date: 2019-04-02
GUANGDONG SHUNDE IND DESIGN INST GUANGDONG SHUNDE INNOVATIVE DESIGN INST
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides an improved way to make nanometer scale particles that are stable when suspended or dissolved in water without damaging them being tested. This makes it easier to detect these tiny objects inside living organisms like bacteria, yeast cell membranes, tissues, etc., which could help researchers better understanding how they work on their body's health issues.

Problems solved by technology

This patented technical problem addressed in that patents relates to improving the performance of magnets due to its special characteristics like strong electrical current carrying capacity, ability to absorb light waves efficiently, good thermal conduction efficiency, durability against environmental factors including moisture, corrosion caused by salts from sea spills, etc., while being able to release them quickly when needed.

Method used

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  • Amphiphilic hydroxyl magnetic bead, and preparation method and application thereof
  • Amphiphilic hydroxyl magnetic bead, and preparation method and application thereof
  • Amphiphilic hydroxyl magnetic bead, and preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0036] Controllable amphiphilic silanol magnetic beads Fe 3 o 4 @SiO 2 -OH / C 0％ preparation method

[0037] First weigh 1g Fe 3 o 4Bare magnetic beads (made according to Li Yadong’s method) were put into a 2000mL three-neck flask, and 1000mL of ethanol, 250mL of water, 10mL of ammonia water, 8mL of tetraethoxysilane and 0mL of methyltrimethoxysilane were added to the three-necked flask, and ultrasonically dispersed for 30 minutes. uniform. The three-neck flask was heated in a water bath at 25°C, and mechanically stirred at a rate of 500 rpm for 24 hours. After the reaction was completed, it was lowered to room temperature to obtain a black magnetic bead suspension solution. After the above reaction solution was attracted by a strong magnet until the supernatant was colorless, the supernatant was discarded, the black precipitate was washed repeatedly with a mixture of water and ethanol, and the sample was placed in a drying oven at 70°C for 24 hours to obtain the controll...

Embodiment 2

[0040] Controllable amphiphilic silanol magnetic beads Fe 3 o 4 @SiO 2 -OH / C 5％ preparation method

[0041] First weigh 1g Fe 3 o 4 Bare magnetic beads (self-made according to Li Yadong's method) were put into a 2000mL three-necked flask, and 1000mL of ethanol, 250mL of water, 10mL of ammonia water, 7.6mL of tetraethoxysilane and 0.4mL of methyltrimethoxysilane were added to the three-necked flask, and ultrasonically 30 minutes to disperse evenly. The three-neck flask was heated in a water bath at 25°C, and mechanically stirred at a rate of 500 rpm for 24 hours. After the reaction was completed, it was lowered to room temperature to obtain a black magnetic bead suspension solution. After the above reaction solution was attracted by a strong magnet until the supernatant was colorless, the supernatant was discarded, the black precipitate was washed repeatedly with a mixture of water and ethanol, and the sample was placed in a drying oven at 70°C for 24 hours to obtain the ...

Embodiment 3

[0044] Controllable amphiphilic silanol magnetic beads Fe 3 o 4 @SiO 2 -OH / C 10％ preparation method

[0045] First weigh 1g Fe 3 o 4 Bare magnetic beads (self-made according to Li Yadong's method) were put into a 2000mL three-necked flask, and 1000mL of ethanol, 250mL of water, 10mL of ammonia water, 7.2mL of tetraethoxysilane and 0.8mL of methyltrimethoxysilane were added to the three-necked flask, and ultrasonically 30 minutes to disperse evenly. The three-neck flask was heated in a water bath at 25°C, and mechanically stirred at a rate of 500 rpm for 24 hours. After the reaction was completed, it was lowered to room temperature to obtain a black magnetic bead suspension solution. After the above reaction solution was attracted by a strong magnet until the supernatant was colorless, the supernatant was discarded, the black precipitate was washed repeatedly with a mixture of water and ethanol, and the sample was placed in a drying oven at 70°C for 24 hours to obtain the...

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Abstract

The present invention relates to an amphiphilic hydroxyl magnetic bead, and a preparation method and application thereof. The preparation method comprises the following steps: mixing 0.5 g-5 g of Fe3O4 bare magnetic beads, 1 ml-20 ml of the hydrophilic silane modifier, 0 ml to 10 ml of the hydrophobic silane modifier, 5 ml-20 ml of the catalyst, and 200 ml to 2500 ml of the solvent for a reactionat 25 DEG C to 80 DEG C; and after the completion of the reaction, collecting the black precipitated material for washing and drying to obtain an amphiphilic hydroxyl magnetic bead. According to the technical scheme of the present invention, surface characteristics of the magnetic bead can be controlled by adjusting the type and the quantity of the hydrophobic silane modifier, and the amphiphilichydroxyl magnetic bead has excellent hydrophilicity and surface reactivity, good biocompatibility, can be used to isolate the nucleic acid or coupled with biologically active substances such as proteins and antibodies to realize the identification of biologically active substances, and has high application value.

Description

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Claims

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Application Information

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Owner GUANGDONG SHUNDE IND DESIGN INST GUANGDONG SHUNDE INNOVATIVE DESIGN INST
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