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Liquid-swellable alginate chitosan composite fiber, preparation method and application thereof

An alginate and composite fiber technology, applied in the direction of alginate rayon, fiber chemical characteristics, absorption pads, etc., can solve the problems of affecting wound healing, slow absorption, poor bacteriostatic and sterilizing effect, etc. Growth of fungi and bacteria, high fluid absorption, and fast wound healing

Pending Publication Date: 2019-04-02
QINGDAO JIFA GROUP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a kind of alginate-chitosan composite fiber which absorbs liquid and its preparation method and application, which solves the problems of slow absorption and poor antibacterial and sterilization effects of alginate-chitosan medical dressings in the prior art. Wound Healing Problems

Method used

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  • Liquid-swellable alginate chitosan composite fiber, preparation method and application thereof
  • Liquid-swellable alginate chitosan composite fiber, preparation method and application thereof
  • Liquid-swellable alginate chitosan composite fiber, preparation method and application thereof

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preparation example Construction

[0028] A kind of preparation method of the alginate-chitosan composite fiber of liquid absorption swelling of the present invention, comprises the following steps:

[0029] 1) Take calcium chloride aqueous solution or calcium ion slow-release system, add chitosan oligosaccharide, stir, adjust the pH value to make the pH value 4.5-6.2, add grass coral extract, peppermint extract, hyaluronic acid and borneol, mix well, get coagulation bath;

[0030] 2) Take alginate, add it into deionized water, stir at 20-25°C for 4-6 hours, filter, stand for defoaming, and stand for 24-48 hours to obtain alginate solution;

[0031] 3) Spray the alginate solution obtained in step 2) into the coagulation bath obtained in step 1) through a spinneret, the temperature of the coagulation bath is 15-25°C, stretching, washing with water, and drying to obtain alginate chitosan Composite fibers.

[0032] Preferably, deionized water is used for washing in step 3), and the temperature of the deionized w...

Embodiment 1

[0036] A kind of preparation method of the alginate-chitosan composite fiber of liquid absorption swelling of the present invention, comprises the following steps:

[0037] 1) Preparation of coagulation bath

[0038] Take calcium chloride, dissolve it in deionized water, and make a calcium chloride aqueous solution with a concentration of 1.10% w / v (g / mL), add chitosan oligosaccharide, stir, add an appropriate amount of dilute hydrochloric acid solution, and adjust the pH value , so that the pH value is 4.98, add grass coral extract, peppermint extract and hyaluronic acid, stir, mix well, and get a coagulation bath;

[0039] The addition of chitosan oligosaccharide is 5% w / v (g / mL) of the volume of deionized water, and the addition of the grass coral extract is 0.5% w / v (g / mL) of the volume of deionized water , the addition of peppermint extract is 0.6% w / v (g / mL) of the volume of deionized water, and the addition of hyaluronic acid is 0.6% w / v (g / mL) of the volume of deioniz...

Embodiment 2

[0045] A kind of preparation method of the alginate-chitosan composite fiber of liquid absorption swelling of the present invention, comprises the following steps:

[0046] 1) Preparation of coagulation bath

[0047] Get calcium gluconate, be dissolved in deionized water, make the calcium gluconate solution that concentration is 0.8%w / v (g / mL), add chitosan oligosaccharide, stir, add appropriate acetic acid solution, adjust pH value, Make the pH value 5.1, add grass coral extract, hyaluronic acid and borneol to get a coagulation bath;

[0048] The addition amount of chitosan oligosaccharide is 2% w / v (g / mL) of the volume of deionized water, and the addition amount of grass coral extract is 1% w / v (g / mL) of the volume of deionized water , the addition of hyaluronic acid is 0.1% w / v (g / mL) of the volume of deionized water, and the addition of borneol is 0.7% w / v (g / mL) of the volume of deionized water;

[0049] The preparation method of oligo-chitosan is: get the chitosan of d...

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Abstract

The invention discloses liquid-swellable alginate chitosan composite fiber, a preparation method and an application thereof. The composite fiber is prepared by a method in which an aqueous solution ofalginate is solidified in a coagulation bath, the mass concentration of the aqueous alginate solution is 3 to 6%; and the coagulation bath comprises the following components in parts by weight: 1 to6 parts of oligochitosan, 0.1 to 1 part of a sarcandra glabra extract, 0 to 1 part of a peppermint extract, 0 to 1 part of hyaluronic acid, 0 to 1 part of borneol, 90 to 100 parts of a calcium chloride solution or a calcium ion sustained release system, and 0.1% to 2.0% a calcium chloride solution or a calcium ion sustained release system. The invention also provides a preparation method of the composite fiber. The active ingredient of the oligochitosan and the like in the invention has uniform distribution in the composite fiber, the composite fiber has a high liquid absorption ratio, and theactive ingredients are fully absorbed for wound repair, the composite fiber can provide different nursing environment for different periods of wound healing, has good sterilization and anti-inflammatory effect, and quick wound healing effect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a liquid-absorbing-swellable alginate-chitosan composite fiber and a preparation method and application thereof. Background technique [0002] Alginic acid is a natural polysaccharide, and its chemical composition is a linear copolymer formed by β-D-mannuronic acid (M) and a-L-guluronic acid (G) through 1,4 bonds, G and M The content of alginic acid has a significant impact on the gelling properties of fibers; alginic acid exists in the cytoplasm in a natural state and plays a role in strengthening the cell wall. Alginic acid combines with various cations in seawater to form various alginic acids Salt. The alginic acid fiber prepared by wet spinning with alginic acid as raw material can be used in textile, clothing, medical and health fields, and is a functional fiber material with high added value. As a medical dressing, alginic acid fiber has been widely used in ...

Claims

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Application Information

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IPC IPC(8): A61L15/46A61L15/28A61L15/40A61L15/44A61L15/20A61L15/42A61L15/62D01F9/04D01F1/10C08B37/08
CPCA61L15/20A61L15/28A61L15/40A61L15/42A61L15/44A61L15/46A61L15/62A61L2300/216A61L2300/232A61L2300/236A61L2300/30A61L2300/402A61L2300/404A61L2300/41A61L2300/412A61L2300/418A61L2300/45C08B37/003D01F1/103D01F9/04C08L5/04C08L5/08
Inventor 徐红梅王占锐陈雪功王京斌衣宏君
Owner QINGDAO JIFA GROUP
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