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A three-dimensional modeling method for sectional image anatomy of human striatum and hippocampal formation

A hippocampal structure and three-dimensional modeling technology, which is applied in the field of three-dimensional anatomical modeling of tomographic images of the striatum and hippocampal structure of the human brain, to achieve convincing data and objective results

Pending Publication Date: 2019-03-29
川北医学院
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  • Abstract
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Problems solved by technology

[0004] To sum up, the problems existing in the existing technology are: the existing technology is limited to the independent discussion of the striatum and the hippocampus, or only studies the structure-function relationship between the striatum and the hippocampus from the molecular biological level

Method used

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  • A three-dimensional modeling method for sectional image anatomy of human striatum and hippocampal formation
  • A three-dimensional modeling method for sectional image anatomy of human striatum and hippocampal formation
  • A three-dimensional modeling method for sectional image anatomy of human striatum and hippocampal formation

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Embodiment 1

[0037] 1 Materials and methods

[0038] (1) Experimental object

[0039] Select 100 adults who were proved to be disease-free by conventional MRI sequence scans, with an average age of 40, and were divided into 5 groups according to age: 16-25, 26-35, 36-45, 46-55, and 56-65 years old, with 20 cases in each group , 10 males and 10 females each, Han nationality. The Mini-Mental State Examination was unremarkable. The exclusion criteria were: central nervous system lesions; history of drug abuse, alcohol abuse, head trauma and family genetic diseases; previous cardiovascular and nervous system surgery or history of mental illness; long-term use of drugs that could affect the nervous system or Those who have taken drugs that affect the nervous system in the past 1 year; those whose collected images do not meet the research requirements.

[0040] (2) MRI scan parameters and observations

[0041] All subjects used GE Signa HDxt 3.0T 3.0T MRI system in the United States, with 8-...

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Abstract

The invention belongs to the technical field of medical model construction, discloses a three-dimensional modeling method for sectional image anatomy of human striatum and hippocampal formation, in which 100 healthy adults without obvious neuropsychiatric disorders and 100 patients with Parkinson's disease, temporal lobe epilepsy and Alzheimer's disease are selected to obtain high-resolution three-dimensional images of the whole brain in horizontal position. The anatomical structures of striatum and hippocampus are measured by stereological quantitative analysis. The data of human striatum andhippocampus measured by MRI are statistically analyzed by SPSS 13.0 software, and the tomographic images are imported into Mimics software to build three-dimensional model of MRI data. The inventiondiscloses the relationship between the striatum and the hippocampal formation, which is explained from three aspects of the normal healthy human body, the disease and the comparison between the normaland the disease, so that the result is more objective, comprehensive, accurate and the data is more convincing.

Description

technical field [0001] The invention belongs to the technical field of medical model construction, and in particular relates to a three-dimensional modeling method of tomographic images of human brain striatum and hippocampus structures. Background technique [0002] At present, the commonly used existing technologies in the industry are as follows: Alzheimer's disease (AD) is the most common dementia, accounting for 50% to 60%, and it is characterized by progressive cognitive dysfunction and memory impairment. A neurodegenerative disease characterized by damage. Domestic survey results show that 10% to 15% of people over 65 years old have cognitive impairment, and most of these people are AD patients. With the aging of the population in China, the number of patients with AD is gradually increasing. Because of its huge social burden, AD has become a hot spot in medical research. The general pathological manifestation of AD is brain atrophy caused by the loss of nerve cells...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T17/00
CPCG06T17/00
Inventor 白桂芹黄小华杨正伟张华彭涛肖如辉
Owner 川北医学院
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