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gptx-1 toxin and its application

1. A technology of gptx-1 and toxin, which is applied to medical preparations containing active ingredients, peptide/protein ingredients, drug combinations, etc., and can solve problems such as side effects, low safety, and low effectiveness

Active Publication Date: 2019-09-17
广东帕派恩生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Currently used sodium channel blockers, such as carbamazepine, lidocaine, and the above-mentioned polypeptide toxins, have multiple types of non-selective effects on sodium channels, which easily cause central and circulatory side effects (such as dizziness, ataxia, insomnia, nausea and headache, etc.), or have defects of low effectiveness and low safety, thus limiting their clinical application and widespread use

Method used

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  • gptx-1 toxin and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The amino acid sequence of the GPTX-1 polypeptide toxin in this example is shown in Table 1 below.

[0049] Table 1

[0050]

[0051] Remark: The F amino acids at the end of SEQ ID NO: 3 to SEQ ID NO: 13 are all aminated, that is, amino groups are added.

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Abstract

The invention primarily relates to Grammostola porter(Gptx-1) toxin and an application thereof. The polypeptide toxin can block Nav1.7 (an alpha subunit family of a voltage-gated sodium channel) effectively and selectively, so that the toxin can be used as a selective sodium ion channel blocking agent which is applied to the fields of molecular mechanism of the related Nav1.7 sodium ion channel, neural signal transfer, disease treatment and the like.

Description

technical field [0001] The present invention relates to a polypeptide substance and its use in medicine preparation, in particular to a polypeptide toxin capable of effectively and selectively blocking Nav1.7 (a voltage-gated sodium channel α subunit family) and its use. Background technique [0002] Voltage-gated sodium channels (VGSCs) are widely distributed and expressed in various tissues of both vertebrates and invertebrates. VGSCs play an important role in the generation and burst of action potentials and in the transmission of nerve signals. Many diseases are closely related to voltage-gated sodium ion channels, such as pain, epilepsy and so on. [0003] VGSCs are high molecular weight, multi-transmembrane glycoproteins on excitatory cell membranes. In 2003, the International Pharmacological Federation announced the nomenclature of VGSCs. The English abbreviation (NaV) means a voltage-sensitive sodium ion channel, where Na stands for a sodium ion channel, and V sta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/00A61K38/16A61P29/00C07K19/00C12N15/11
Inventor 潘伟飚
Owner 广东帕派恩生物科技有限公司
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