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Temperature responsive nano composite material capable of slowly releasing oxygen gas as well as preparation method and application of temperature responsive nano composite material

A nano-composite material and temperature-responsive technology, which is applied in the direction of splitting materials, medical preparations of non-active ingredients, wave energy or particle radiation treatment materials, etc., can solve the problem of insensitivity of tumor cells to chemotherapeutic drugs or radiation therapy, and achieve The preparation method is simple, and the effect of improving the tumor hypoxic microenvironment

Active Publication Date: 2019-03-19
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the hypoxic microenvironment further enhances the malignancy of tumors, resulting in insensitivity of tumor cells to chemotherapeutic drugs or radiotherapy

Method used

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  • Temperature responsive nano composite material capable of slowly releasing oxygen gas as well as preparation method and application of temperature responsive nano composite material
  • Temperature responsive nano composite material capable of slowly releasing oxygen gas as well as preparation method and application of temperature responsive nano composite material

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Embodiment 1

[0020] 1. Preparation of hollow mesoporous silica nanoparticles (hollow mesoporous silica, HMS):

[0021] Step 1.1:

[0022] Absolute ethanol (74mL), deionized water (10mL) and ammonia water (3.14mL) were placed in a 30°C constant temperature water bath for magnetic stirring, and mixed uniformly as a precursor reaction solution for subsequent reactions; ethyl orthosilicate ( TEOS, 6mL) was quickly added to the above precursor reaction solution, and reacted at 30°C for 1h to obtain a milky white colloidal solution;

[0023] Centrifuge the white colloidal solution, wash it several times with ethanol, and dry it in vacuum to obtain solid silica nanoparticles (SSNs);

[0024] The prepared SSNs (200mg) were dispersed into 40mL deionized water and ultrasonicated for 15min; at the same time, hexadecyltrimethylammonium bromide (C 16 TAB, 300mg), deionized water (60mL), absolute ethanol (60mL) and ammonia water (1.3mL) were uniformly mixed and stirred for 30min, all were added to the...

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Abstract

The invention discloses a temperature responsive nano composite material capable of slowly releasing oxygen gas as well as a preparation method and application of the temperature responsive nano composite material. The nano composite material takes a hollow mesoporous silicon oxide nanoparticle as a carrier and potassium ferrate is loaded in the hollow mesoporous silicon oxide nanoparticle; and awater-insoluble temperature sensitive compound for blocking the potassium ferrate is also loaded on the hollow mesoporous silicon oxide nanoparticle. Under an in-vitro environment, the temperature isrelatively low and does not reach a melting point of the temperature sensitive compound, so that the potassium ferrate in pores of the nano composite material cannot be in contact with water; after the material enters a body, the partial temperature of a tumor is raised under the conditions of body temperature, partial hot compress of the tumor or ultrasonic irradiation on tumor focuses; after reaching the melting point, the temperature sensitive compound is melted; and after the potassium ferrate is in contact with the water in body fluid, the oxygen gas is produced on the partial tumor. A preparation prepared from the nano composite material has an application prospect of improving an anoxic microenvironment of the tumor.

Description

technical field [0001] The invention relates to the technical field of nano-biological materials, in particular to a temperature-responsive oxygen-releasing nano-composite material and its preparation method and application. Background technique [0002] The hypoxic microenvironment is an important feature of solid tumors. Under hypoxic conditions, tumor cells secrete a variety of angiogenic growth factors to promote the formation of abnormal blood vessels. At the same time, in order to find a more suitable soil, the invasion and metastasis ability of tumor cells will be further improved. In addition, the hypoxic microenvironment further enhances the malignancy of tumors, making tumor cells insensitive to chemotherapeutic drugs or radiation therapy. The hypoxic microenvironment is an important factor for the poor prognosis of tumors. Improving the tumor hypoxic microenvironment is expected to become a new method to improve the efficacy of solid tumors. Contents of the i...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K33/00A61K9/51A61K47/04A61K47/10A61K47/12A61K47/06A61P35/00
CPCA61K41/0033A61P35/00A61K9/0004A61K9/5115A61K9/5123A61K33/00
Inventor 符静珂郝永强姜闻博富灵杰贺超马思聪
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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