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Antitumor composition and application thereof in preparation of antitumor medicine or medicine for inhibiting cancer cells, as well as antitumor medicine

An anti-tumor drug, anti-tumor technology, applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., to achieve the effect of improving anti-tumor effects, reducing the risk of drug resistance, and reducing the dosage of single drugs

Active Publication Date: 2019-03-12
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pharmaceutical composition of mercaptopurine, thioguanine, artemisinin and its derivatives has not been reported in the treatment of tumors

Method used

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  • Antitumor composition and application thereof in preparation of antitumor medicine or medicine for inhibiting cancer cells, as well as antitumor medicine
  • Antitumor composition and application thereof in preparation of antitumor medicine or medicine for inhibiting cancer cells, as well as antitumor medicine
  • Antitumor composition and application thereof in preparation of antitumor medicine or medicine for inhibiting cancer cells, as well as antitumor medicine

Examples

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preparation example Construction

[0033] The preparation method of the anti-tumor drug of the present invention is not limited, the two anti-tumor components can be directly mixed to make a preparation, or separately mixed with / or corresponding auxiliary materials to make a preparation, and then packaged together in a conventional manner in the art , or mixed with the corresponding excipients separately and then mixed to make a preparation.

[0034] The antitumor drug of the present invention can be a pharmaceutical preparation suitable for gastrointestinal administration, or a pharmaceutical preparation for parenteral administration. Pharmaceutical preparations for gastrointestinal administration are preferred.

[0035] The first anti-tumor component and the second anti-tumor component in the anti-tumor composition and anti-tumor drug of the present invention can be administered simultaneously or separately in any order. For the way of separate administration, there is no special requirement for the time int...

Embodiment 1

[0052] The anti-tumor composition of the present embodiment is made up of the first anti-tumor component and the second anti-tumor component, the first anti-tumor component is mercaptopurine (7M), and the second anti-tumor component is dihydroartemisinin ( DHA), the molar ratio of the first anti-tumor component to the second anti-tumor component is 1:1.

Embodiment 2

[0054] The anti-tumor composition of the present embodiment is made up of the first anti-tumor component and the second anti-tumor component, the first anti-tumor component is mercaptopurine (7M), and the second anti-tumor component is dihydroartemisinin ( DHA), the molar ratio of the first anti-tumor component to the second anti-tumor component is 1:4.

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Abstract

The invention relates to an antitumor composition and application thereof in preparation of an antitumor medicine or a medicine for inhibiting cancer cells, as well as the antitumor medicine, and belongs to the technical field of medicine preparation. The antitumor composition involved in the invention comprises a first antitumor component and a second antitumor component; the first antitumor component is one or two of mercaptopurine and thioguanine or a salt or salts of one or two of the mercaptopurine and the thioguanine; the second antitumor component is dihydroartemisinin, and the molar ratio of the first antitumor component to the dihydroartemisinin is 1:(1-4); or the second antitumor component is an artemisinin derivative, and the molar ratio of the first antitumor component to artemisinin or the dihydroartemisinin generated through metabolism of the second antitumor component is 1:(1-4); and an antitumor compound capable of generating the dihydroartemisinin through metabolism isone or a combination of several of artesunate, artemether and arteether. The two antitumor components of the antitumor composition involved in the invention have a synergy effect.

Description

technical field [0001] The invention relates to an anti-tumor composition and its application in the preparation of anti-tumor or cancer cell inhibiting drugs and anti-tumor drugs, belonging to the technical field of drug preparation. Background technique [0002] Malignant tumors are still incurable and have become a prominent public health problem in the world today. According to the World Health Organization, 1 out of every 8 deaths in the world is currently caused by cancer, which is higher than the total number of deaths caused by AIDS, malaria and tuberculosis. According to data from the International Cancer Research Center (IARC), there were about 10.9 million new cases of malignant tumors in the world in 2002, and 6.7 million deaths. According to a research report provided by IARC, by 2020, the number of new cancer patients worldwide will reach 15 million each year. According to WHO statistics, in 2012, the number of new cancer cases and deaths in the world increas...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K31/52A61K31/357A61K31/366A61P35/00A61P35/02
CPCA61K31/357A61K31/366A61K31/52A61K31/522A61P35/00A61P35/02A61K2300/00
Inventor 王继刚谷丽维徐承超朱永平刘丹丹孙鹏孟雨晴孙继超李玉洁廖福龙高鹏吕明朱晓新
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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