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Medical use of pedunculoside

A technology of pedicel glucoside and medicine, which is applied in the field of medicine, and can solve the problem that there is no report on the therapeutic effect

Inactive Publication Date: 2019-03-08
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current report on the activity of pedicel glucoside shows that it has the activity of inhibiting mouse ear swelling and treating hyperlipidemia, but there is no report on the therapeutic effect of colorectal cancer, especially colitis-associated cancer (CAC)

Method used

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  • Medical use of pedunculoside
  • Medical use of pedunculoside
  • Medical use of pedunculoside

Examples

Experimental program
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Effect test

Embodiment 1

[0021] The present invention will be further described below in conjunction with specific examples, but it does not mean that the present invention is limited thereto. Example 1: The preventive and therapeutic effects of pedicel glucoside on colitis-associated colorectal cancer:

[0022] Animals used: SPF grade C57BL / 6 mice, weighing 11-13g, provided by the Experimental Animal Center of Guangdong University of Traditional Chinese Medicine, license number: SCXK (Guangdong) 2013-0034. Certificate of Conformity NO.44007200045799.

[0023] C57BL / 6 mice aged 6-8 weeks were used, and azomethane (AOM) 12.5mg / kg was injected intraperitoneally in the first week, and 2.5% dextran sodium sulfate (DSS) was given free drinking water in the second week for 5 consecutive days. After a two-week interval (normal drinking and feeding), give 2.5% DSS free drinking water again in the fifth week for 5 consecutive days, and then give another two-week interval (normal drinking and feeding) and give...

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Abstract

The invention relates to the technical field of medicine, and relates to a medical use of pedunculoside, in particular to application of the pedunculoside which is a natural source monomer compound topreparation of a colorectal cancer drug. The minimum effective dose of the pedunculoside is: 20 mg / kg. The pedunculoside can be prepared into a pharmaceutical composition with a pharmaceutically acceptable carrier, and the pedunculoside or the composition thereof can be prepared according to the conventional method in the art and can be applied to an enteric or parenteral or local way, includingoral administration, hypogloeeis, percutaneous administration, transmuscular or subcutaneous administration, skin mucosas, veins, urethra, vagina and the like.

Description

technical field [0001] The present invention relates to the technical field of medicine, and relates to the medical use of pedicel glucoside, in particular to the application of pedicel pine glucoside in the preparation of medicines for preventing or treating colorectal cancer. Background technique [0002] With the improvement of my country's living standards, high-protein diets have become the mainstream of my country's diet. The incidence of colorectal cancer in my country is steadily increasing along with the dietary habits of lack of fiber. At present, less than 20% of the incidence of colorectal cancer can be attributed to genetic factors, while most of the incidence of colorectal cancer are related to external factors. [0003] In colorectal cancer, there is a type of colorectal pathogenesis in which inflammatory bowel diseases such as colitis occur first, and then colorectal tumors occur. We call this type of colorectal cancer colitis-associated cancer (CAC) [00...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61P35/00
CPCA61K31/7024A61P35/00
Inventor 李宁陈刚
Owner SHENYANG PHARMA UNIVERSITY
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