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Disulfiram-metal organic framework compound as well as preparation method and application thereof

A metal-organic framework and disulfiram technology, applied in the field of complexes, can solve problems such as disulfiram-like reactions in patients, and achieve the effects of reducing treatment costs, reducing toxic and side effects, and inhibiting tumor cell proliferation

Inactive Publication Date: 2019-03-08
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the dosage form of DSF is mainly oral tablets, which need to be taken in larger doses to achieve effective anti-tumor effects, but it will cause patients to be prone to side effects such as disulfiram-like reactions

Method used

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  • Disulfiram-metal organic framework compound as well as preparation method and application thereof
  • Disulfiram-metal organic framework compound as well as preparation method and application thereof
  • Disulfiram-metal organic framework compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] This example 1 provides a disulfiram-metal organic framework complex (DSF-ZIF-8), which consists of the following components by weight: 350 parts of disulfiram, 75 parts of zinc acetate dihydrate and 2-formazan 125 parts of imidazoles.

[0028] The preparation method of the DSF-ZIF-8 comprises the following steps: adding disulfiram, zinc acetate dihydrate and 2-methylimidazole into N,N'-dimethylformamide to dissolve (N,N'-di The amount of methylformamide used is to make each component dissolve), stir at room temperature for 12 hours, collect the reaction product by centrifugation, and finally wash the reaction product three times with equal volumes of N,N'-dimethylformamide and methanol , you can.

Embodiment 2

[0030] This Example 2 provides a disulfiram-metal organic framework complex (DSF-ZIF-8), which consists of the following components by weight: 200 parts of disulfiram, 60 parts of zinc acetate and 4-methylimidazole 80 servings. The preparation method refers to Example 1.

Embodiment 3

[0032] This embodiment 3 provides a disulfiram-metal organic framework compound (DSF-ZIF-8), which consists of the following components by weight: 100 parts of disulfiram, 50 parts of zinc nitrate hexahydrate and 5-formazan 60 parts of imidazoles. The preparation method refers to Example 1.

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Abstract

The invention discloses disulfiram-metal organic framework compound as well as a preparation method and application thereof. The disulfiram-metal organic framework compound is prepared from the following ingredients in parts by weight: 1 to 3,000 parts of disulfiram, 1 to 600 parts of zinc salt, and 1 to 6,000 parts of imidazole derivative. Experiments prove that the disulfiram-metal organic framework compound disclosed by the invention can effectively inhibit tumor cell proliferation under a low dosage condition; an antitumous effect of the disulfiram-metal organic framework compound is obviously superior to that of DSF; furthermore, the effective dosage is low, toxic and side effects caused by DSF are effectively reduced, and treating cost of a patient is also reduced. Meanwhile, the disulfiram-metal organic framework compound has good structure stability under the physiological condition (pH 7.4) and can accelerate DSF release under the tumor microenvironment (pH 5.0 to pH 6.5).

Description

technical field [0001] The invention relates to a compound, in particular to a disulfiram-metal organic framework compound and its preparation method and application. Background technique [0002] Malignant tumors have become a major disease that threatens human health. Among them, breast cancer is the most common female malignant tumor in the world and the leading cause of cancer death in women worldwide. In recent years, with the in-depth research on the biological behavior and molecular mechanism of tumors, many new treatment methods such as targeted therapy and immunotherapy have emerged, which have greatly improved the survival of tumor patients. Nevertheless, the effect of the above-mentioned treatment methods is still not satisfactory. Therefore, some researchers have tried to focus on previously approved drugs that are cheap and have anti-tumor activity, such as disulfiram (DSF). Disulfiram (disulfiram, DSF), also known as disulfiram, is a dithiocarbamate drug that...

Claims

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Application Information

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IPC IPC(8): A61K31/145A61K47/34A61P35/00
Inventor 肖计生郭晓燕王奇
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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