Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Water soluble star-shaped polymer with beta-cyclodextrin being core and preparation method of the polymer

A technology of star polymer and cyclodextrin, which is applied in the field of water-soluble star polymer and its preparation, can solve the problems of inhomogeneity of polymer arms and uncontrollable polymer structure, and achieve controllable number of arms and ensure uniformity sexual, structured effects

Active Publication Date: 2019-03-01
SOUTHWEST PETROLEUM UNIV
View PDF8 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method based on β-cyclodextrin for the uncontrollable polymer structure and non-uniform polymer arms in the existing preparation method of star-shaped polymers with β-cyclodextrin as the core. Water-soluble star polymer with controllable core structure and its preparation method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Water soluble star-shaped polymer with beta-cyclodextrin being core and preparation method of the polymer
  • Water soluble star-shaped polymer with beta-cyclodextrin being core and preparation method of the polymer
  • Water soluble star-shaped polymer with beta-cyclodextrin being core and preparation method of the polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0038] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0039] It should be understood that terms such as "having", "comprising" and "including" as used herein do not entail the presence or addition of one or more other elements or combinations thereof.

[0040] A method for preparing polydimethylaminoethyl methacrylate-polyacrylic acid PDMAEMA-PAA, select dimethylaminoethyl methacrylate as reaction monomer, (2-((butylsulfanyl)-thiocarbonyl ))-propionic acid is a chain transfer agent, and the specific preparation steps are as follows:

[0041] Step S1, performing reversible addition-fragmentation chain transfer polymerization (raft) reaction between the reaction monomer and the chain transfer agent to synthesize a water-soluble chain polymer with controllable structure and narrow molecular weight distribution, and perform thiol co...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a structure-controllable water soluble star-shaped polymer with beta-cyclodextrin being a core. A preparation method includes: S1) performing a reversible addition-fragmentation chain transfer polymerization reaction to synthesize the structure-controllable water soluble star-shaped polymer which is narrow in molecular weight distribution, and performing sulfhydryl conversion to the chain terminal; S2) modifying a beta-cyclodextrin core to introduce a C=C bond; S3) performing a sulfhydryl-alkene click chemical reaction to graft the chain polymer onto the modified beta-cyclodextrin core to form the structure-controllable water soluble star-shaped polymer with beta-cyclodextrin being a core. In the method, the reaction monomer is acrylates or acrylamides, and the chain transfer agent is dithio ester or trithio ester. The polymer is prepared in a manner of "firstly arm and secondly core", wherein all the polymer arms have been accurately represented before "core connection", so that the polymer has controllable and definite structure and the uniformity of the polymer arms is guaranteed; in addition, by regulation of the arm-core ratio of the polymer, the numberof the arms is controllable.

Description

technical field [0001] The invention belongs to the technical field of polymer synthesis, and in particular relates to a structure-controllable water-soluble star polymer based on β-cyclodextrin as the core and a preparation method thereof. Background technique [0002] β-cyclodextrin has a unique structural feature of hydrophobic inside and hydrophilic outside. Its inner hydrophobic cavity can envelop organic molecules of appropriate size, and its outer hydrophilic hydroxyl has a chelating effect on high-valent metal ions, so It has certain stereo selection and recognition performance. However, since the solubility of β-cyclodextrin in water is only 1.64%, when it forms clathrates with other substances, its water solubility is lower and it is easy to crystallize out of the solution, which greatly limits its application. By modifying β-cyclodextrin and using it as the core to prepare a variety of star-shaped polymers, it has been widely used in drug loading and biopharmaceu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/02C08B37/16C08F293/00C08F220/34C08F220/18C08F2/38C08F8/00
CPCC08B37/0012C08F2/38C08F8/00C08F220/18C08F220/34C08F293/005C08F2438/03C08G81/02C08F220/1804
Inventor 薛艳王新勇张波鹿嘉悦
Owner SOUTHWEST PETROLEUM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com