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Composition for preventing and treating osteoporosis, preparation method and application thereof

A technology for osteoporosis and composition, which is applied in the field of medicine and achieves the effects of preventing bone loss, wide source of raw materials and inhibiting differentiation

Active Publication Date: 2020-09-01
久荫健康管理(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the use of propolis alcohol extract, bee pollen water extract, modified pectin powder and donkey-hide gelatin powder for the prevention and treatment of osteoporosis

Method used

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  • Composition for preventing and treating osteoporosis, preparation method and application thereof
  • Composition for preventing and treating osteoporosis, preparation method and application thereof
  • Composition for preventing and treating osteoporosis, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of embodiment 1 composition powder of the present invention (one)

[0037] The weight ratio of each natural product is: 10g of propolis alcohol extract, 10g of bee pollen water extract, 70g of modified pectin powder, and 10g of donkey-hide gelatin powder.

[0038] (1) Preparation of propolis ethanol extract: Chinese poplar propolis or Brazilian propolis raw materials were frozen and pulverized, refluxed and extracted with 70% ethanol solution at 75°C for 2 hours, and the extract was freeze-dried and pulverized through a 60-mesh sieve.

[0039](2) Preparation of water extract of bee pollen: ultrafine pulverization of camellia pollen, lotus pollen or rape pollen, hot soaking in distilled water at 90°C for 3 hours, freeze-dried extract, and pulverizing through a 60-mesh sieve.

[0040] (3) Preparation of modified pectin: Pectin from citrus, carrot, silkworm excrement, sunflower dish and other sources is through alkaline hydrolysis (1% NaOH aqueous solution ...

Embodiment 2

[0043] The preparation of embodiment 2 composition powder of the present invention (two)

[0044] The weight ratio of each natural product is: 5g of propolis alcohol extract, 15g of bee pollen water extract, 65g of modified pectin powder, and 15g of donkey-hide gelatin powder.

[0045] (1) Preparation of propolis ethanol extract: Chinese poplar propolis or Brazilian propolis raw materials were frozen and pulverized, refluxed and extracted with 75% ethanol solution at 70°C for 3 hours, and the extract was freeze-dried and pulverized through a 60-mesh sieve.

[0046] (2) Preparation of water extract of bee pollen: superfine pulverization of camellia pollen, lotus pollen or rape pollen, hot dipping in distilled water at 95°C for 3 hours, freeze-dried extract, and crushing through a 60-mesh sieve.

[0047] (3) Preparation of modified pectin: Pectin from sources such as citrus, carrot, silkworm excrement, and sunflower dish is subjected to alkaline hydrolysis (NaOH aqueous solution...

Embodiment 3

[0050] The preparation of embodiment 3 composition powder of the present invention (three)

[0051] The ratio of parts by weight of each natural product is: 1 g of propolis ethanol extract, 1 g of bee pollen water extract, 10 g of modified pectin powder, and 1 g of donkey-hide gelatin powder.

[0052] (1) Preparation of propolis ethanol extract: Chinese poplar propolis or Brazilian propolis raw materials were frozen and pulverized, refluxed and extracted with 75% ethanol solution at 70°C for 4 hours, and the extract was freeze-dried and pulverized through a 60-mesh sieve.

[0053] (2) Preparation of water extract of bee pollen: ultrafine pulverization of camellia pollen, lotus pollen or rape pollen, hot soaking in distilled water at 80°C for 4 hours, freeze-dried extract, and pulverizing through a 60-mesh sieve.

[0054] (3) Preparation of modified pectin: Pectin from sources such as citrus, carrot, silkworm excrement, and sunflower dish is subjected to alkaline hydrolysis (Na...

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Abstract

The invention relates to a composition for preventing and treating osteoporosis and its preparation method and application. The composition is made of raw materials with the following proportions by weight: 1-20 parts of propolis ethanol extract and 1-20 parts of bee pollen aqueous extract. 20 parts, modified pectin powder 10-70 parts, donkey hide gelatin powder 1-20 parts. The propolis alcohol extract is obtained by refluxing the propolis raw material with 70%-75% ethanol solution under heating conditions of 70-75°C for 2-4 hours, freeze-drying and then crushing; the bee pollen aqueous extract is the bee pollen raw material It is obtained by leaching with distilled water for 2-4 hours under heating conditions of 80-95°C, freeze-drying and then crushing; the modified pectin powder is obtained by alkali hydrolysis or enzymatic hydrolysis of pectin raw materials with a molecular weight of 2000-30000, Modified pectin with an esterification degree of 5%-35%. Cell, animal and clinical experiments have confirmed that the composition of the present invention has a very significant effect in preventing and treating osteoporosis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composition for preventing and treating osteoporosis, a preparation method and application thereof. Background technique [0002] Osteoporosis is a silent disease that seriously affects the quality of life of the elderly. It has no obvious clinical symptoms in the early stage, and it is difficult to be discovered. Most of them are not intervened until fractures occur. There are more than 200 million osteoporosis patients in the world every year, and about 89 million osteoporosis patients suffer from fractures. According to the current prevalence rate of osteoporosis of 13%, the annual cost of fractures caused by osteoporosis is as high as 1 billion US dollars. With the advent of my country's aging society, the prevention and treatment of osteoporotic fractures has become an important social public health task. Therefore, the development of drugs for the prevention and treatm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/644A61K36/00A61P19/10A23L33/10A23L21/20A61K31/732A61K35/36A61K35/64
CPCA61P19/10A23L21/20A23L33/10A61K31/732A61K35/36A61K35/63A61K35/64A61K35/644A61K36/00A23V2002/00A61K2300/00A23V2200/306
Inventor 朱威李英华
Owner 久荫健康管理(上海)有限公司
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