Method and device for increasing nitric acid utilization rate in production of metronidazole, and application

Abstract

The invention discloses a device for increasing the nitric acid utilization rate in production. The device comprises a reaction kettle, a flow guiding tube, a gas distributor and a dripping funnel; the reaction kettle is provided with an upper cover, the upper cover is provided with a hole, and a discharging valve is arranged at the lower end of the upper cover; the flow guiding tube penetrates into the upper cover to be arranged in the reaction kettle; the dripping funnel is inserted into the flow guiding tube; and the gas distributor is arranged at the bottom of the reaction kettle. The device has the beneficial effects that 1, nitrogen oxide generated by the device is directly converted into nitric acid in a reaction system, and thus the utilization rate of nitric acid raw materials isincreased; 2, absorption liquid is replaced with an oxygen-containing reaction solution, polluted wastewater is not generated, an absorbent does not need to be purchased additionally, and only air needs to be utilized to increase oxygen is increased in reaction liquid through air; and 3, the nitrogen oxide generated in the reaction liquid is not mixed with inert gas, and thus the problem that theinert gas mixed with the nitrogen oxide is exhausted into air, and consequently the air is polluted is avoided, and the problem that the nitrogen oxide is diluted by the inert gas, the absorption rateis greatly decreased, and consequently the cost of absorption equipment is high is also avoided.

Description

technical field [0001] The invention belongs to the fields of chemical synthesis and resource recovery, and specifically relates to a method, device and application for improving the utilization rate of nitric acid in the production of metronidazole and glyoxylic acid. Background technique [0002] Metronidazole is white or yellowish crystal or crystalline powder, used for the treatment of intestinal and parenteral amoebiasis (such as amebic liver abscess, pleural amoebiasis, etc.). It can also be used to treat vaginal trichomoniasis, cylindrosis, skin leishmaniasis, and guinea worm infection. At present, it is also widely used in the treatment of anaerobic infection, and is regarded as the drug of choice for anti-anaerobic bacteria by the World Health Organization (WHO). [0003] Glyoxylic acid is composed of an aldehyde group (-CHO) and a carboxyl group (-COOH). Its structural formula is HOCCOOH, and its molecular formula is C 2 h 2 o 3 . Flavoring and fixing agents f...

AI Technical Summary

Problems solved by technology

The current process has problems such as nitrogen oxides polluting the environment, low utilization rate of nitric acid, and high cost of absorption equipment.

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