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Application of TET (ten-eleven translocation) protein in treatment of depression

A depression and protein technology, applied in the biological field, can solve the problems of large side effects, insufficient effective cure rate of patients with depression, and drug side effects that plague patients with depression, etc., and achieve the effect of avoiding side effects.

Inactive Publication Date: 2019-02-22
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the effective cure rate of depression patients is less than 2 / 3, and obvious drug side effects plague most depression patients
The original drugs for the treatment of depression were developed based on affecting the reuptake of the neurotransmitter 5-HT. This type of drug has a certain effect on the treatment of depression, but the side effects are relatively large

Method used

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  • Application of TET (ten-eleven translocation) protein in treatment of depression
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  • Application of TET (ten-eleven translocation) protein in treatment of depression

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Embodiment Construction

[0019] The present invention is described in further detail now in conjunction with accompanying drawing.

[0020] figure 1 is the tail suspension experiment data diagram of the present invention, figure 2 is the forced swimming experiment data diagram of the present invention, image 3 It is the QPCR result data chart of detecting TET1 gene mRNA level of the present invention, Figure 4 It is the QPCR result data chart of detecting TET2 gene mRNA level of the present invention, Figure 5 It is the QPCR result data figure of detecting TET3 gene mRNA level of the present invention, Figure 6 Co-immunoprecipitation experiment control chart of the present invention, Figure 7 The visualized sequencing analysis chart of the present invention.

[0021] The application of a TET protein in the treatment of depression, and the application of the TET1 protein in the treatment of depression drugs. The TET1 protein is used as a target of drugs for treating depression. The sequenc...

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Abstract

The invention relates to the technical field of biology, in particular to application of TET (ten-eleven translocation) protein in treatment of depression. According to the application of the TET1 (ten-eleven translocation 1) protein in drugs for treating depression, data acquired in mouse experiments show that the inhibition and even knockout of the TET1 (ten-eleven translocation 1) protein do not bring any other unusual conditions to mice, and therefore the TET1 (ten-eleven translocation 1) protein serving as a target spot of a target drug can avoid the side effects of an original drug for treating depression.

Description

technical field [0001] The invention relates to the field of biotechnology, especially the application of TET protein in treating depression. Background technique [0002] Depression is an attack form of manic depression, with low emotion, slow thinking, and decreased speech and movement, slowness as typical symptoms. Depression seriously plagues the life and work of patients, and brings a heavy burden to families and society. About 15% of patients with depression die by suicide. A joint study by the World Health Organization, the World Bank and Harvard University shows that depression has become the second largest disease burden in China. [0003] At present, the effective cure rate of patients with depression is less than 2 / 3, and the obvious side effects of drugs plague most patients with depression. Therefore, the study of depression has become a hot and difficult point, and the further research on the pathogenesis and the development of new drugs are the top priority ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61P25/24
CPCA61K45/00A61P25/24
Inventor 徐兴顺金鹏孙淼苗志刚程郢
Owner SUZHOU UNIV
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